IL-35 is elevated in clinical and experimental sepsis and mediates inflammation

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Ju CaoLiping Zhang

Abstract

Sepsis carries considerable morbidity and mortality. IL-35 is a newly described cytokine, which plays a regulatory role in infection and immunity. In this study, we found that IL-35 concentration in serum samples from adult or child patients with sepsis was significantly higher compared with that from healthy controls. IL-35 gradually increased according to sepsis severity. Increased serum IL-35 was associated with LOD (Logistic Organ Dysfunction) or SAPS II (Simplified Acute Physiology Score) scores, and correlated with markers of inflammation. In murine abdominal sepsis, administration of anti-IL-35 p35 antibodies significantly diminished dissemination of the bacteria in septic animals, which was accompanied by enhanced local neutrophil recruitment and early increased release of inflammatory cytokines and chemokines. Therefore, sepsis is associated with enhanced release of IL-35. In abdominal sepsis, IL-35 likely facilitates bacterial dissemination. IL-35 plays a major role in the immunopathogenesis of sepsis.

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Citations

Oct 19, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei-Xia DuJia-Lin Yu
Jun 24, 2017·International Immunopharmacology·Siqi LiuZhenjing Jin
Nov 29, 2017·Frontiers in Cellular and Infection Microbiology·Xue ShaoZhenjing Jin
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Jun 9, 2020·Frontiers in Immunology·Zhao MengmengLi Hui-Ping
Nov 28, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Qian HuangYuxiu Duan
Nov 18, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cheng YeDario A A Vignali

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