IL-35 may maintain homeostasis of the immune microenvironment in periodontitis

Experimental and Therapeutic Medicine
Ying JinXiao-Ping Lin

Abstract

T lymphocyte cells, including regulatory T (Treg) and T helper 17 cells, have important roles in the human periodontium. However, the basis for Treg cytokine expression in various compartments of the periodontium remains unclear. The aim of the present study was to investigate the expression of interleukin (IL)-35 in the peripheral blood mononuclear cells (PBMCs) and periodontal tissues of patients with chronic periodontitis (CP), with a view to understanding its role in this disease, and ultimately providing improved treatments. Peripheral blood, periodontal tissues and gingival crevicular fluids (GCFs) were collected from patients with CP or impacted teeth, the latter serving as healthy controls. The expression levels of IL-35 subunit mRNAs in PBMCs and periodontal tissues were determined using reverse transcription-quantitative polymerase chain reaction, while the IL-35 protein expression in GCFs and sera was quantified by ELISA. The relative expression of IL-35 subunit mRNAs in the affected tissues of patients with CP was significantly higher compared with that in samples from healthy controls (P<0.05). The mean concentration of IL-35 protein in the GCFs and sera of patients with periodontitis was also significantly higher ...Continue Reading

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Citations

Apr 22, 2020·Journal of Developmental Origins of Health and Disease·Grazielle RodriguesAdriana Lino-Dos-Santos-Franco
Mar 22, 2020·International Journal of Molecular Sciences·Yosuke KamiyaAkio Mitani
Apr 16, 2020·International Journal of Molecular Sciences·Erica CostantiniGiovanna Murmura
Jan 5, 2021·Cancer Immunology, Immunotherapy : CII·Kirti KajalGaurisankar Sa
Dec 18, 2020·Journal of Clinical Medicine·Małgorzata KozakAndrzej Pawlik

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