IL-35 Pretreatment Alleviates Lipopolysaccharide-Induced Acute Kidney Injury in Mice by Inhibiting NF-κB Activation

Inflammation
Linkun HuJianquan Hou

Abstract

Septic acute kidney injury (AKI) is a public health problem with high mortality. Suppression of over-active inflammation is considered as a promising strategy for septic AKI. In this study, we evaluated the prophylactic effect of interleukin (IL)-35, the unique immune-suppressive member of IL-12 cytokine family, on lipopolysaccharide (LPS)-induced AKI in mice, and found that compared with control mice given empty vector, mice pretreated with plasmid encoding IL-35 (pIL-35) significantly improved renal function indicated by reduced blood urea nitrogen (BUN) and serum creatinine (SCr), and obviously alleviated renal pathological changes. To explore the underlying protective mechanisms, we found that pIL-35 treatment could robustly reduce the production of renal pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), with no significant impact on IL-10, an anti-inflammatory cytokine. Furthermore, our results revealed that IL-35 pretreatment could potentially inhibit the activation of renal NF-κB signaling pathway in LPS-induced AKI mice. Taken together, our study indicated that IL-35 pretreatment could efficiently prevent LPS-induced AKI via inhibiting NF-κB activation and reducing pro-inflammatory cytokine production, and it might r...Continue Reading

References

Feb 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H NeveuP Landais
Nov 5, 1999·The Journal of Biological Chemistry·A J SchotteliusA S Baldwin
Nov 27, 2004·The New England Journal of Medicine·Rinaldo BellomoLi Wan
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawTom Rosenal
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Lakhmir S ChawlaWilliam L Macias
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Feb 1, 2008·Journal of the American Society of Nephrology : JASN·Dmitry N GrigoryevHamid Rabb
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilie BardelOdile Devergne
Nov 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Su SongOliver Witzke
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Mar 25, 2011·Kidney International·Lakhmir S ChawlaCarlos E Palant
May 14, 2011·Journal of the American Society of Nephrology : JASN·Abolfazl Zarjou, Anupam Agarwal
Jun 8, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Paweena SusantitaphongUNKNOWN Acute Kidney Injury Advisory Group of the American Society of Nephrology
Jan 22, 2014·Nature Reviews. Nephrology·Oleksa Rewa, Sean M Bagshaw
May 23, 2014·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M Joannidis, H P Kierdorf
Aug 22, 2014·American Journal of Physiology. Renal Physiology·Asada LeelahavanichkulPeter S T Yuen
Nov 22, 2014·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Hui ShenLuo Zhang
Jan 16, 2016·Annual Review of Medicine·Anna Zuk, Joseph V Bonventre
Jan 19, 2016·Mathematical Biosciences and Engineering : MBE·Avner Friedman, Kang-Ling Liao
Feb 14, 2016·Immunity·Meghan E TurnisDario A A Vignali
Feb 18, 2016·Scientific Reports·Fan ZhangCheng-bin Wang
May 7, 2016·International Journal of Molecular Sciences·Pu DuannPei-Hui Lin
Aug 31, 2016·Nature Reviews. Nephrology·Joerg C SchefoldStephan von Haehling
Oct 4, 2016·Inflammation·Shi-Yang GuanHai-Feng Pan
Nov 20, 2016·European Journal of Immunology·Fatima ManzoorRoland Tisch
Nov 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyosuke KanaiOsamu Yoshie
Dec 14, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shenyi JiangJing Lu

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Citations

Mar 27, 2018·The Tohoku Journal of Experimental Medicine·Di HeBo Liu
Jan 29, 2021·Mediators of Inflammation·Chuanchuan ShiJianguo Li

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
GraphPad

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