IL-4 -588C>T polymorphism and IL-4 receptor alpha [Ex5+14A>G; Ex11+828A>G] haplotype concur in selecting H. pylori cagA subtype infections

Clinica Chimica Acta; International Journal of Clinical Chemistry
Carlo-Federico ZambonMario Plebani

Abstract

The Th2 cytokine IL-4 might limit H. pylori associated gastric inflammation and favour H. pylori clearance. The aim of the study was to verify whether IL-4 -588C>T SNP, or two SNPs of the gene coding the alpha chain of IL-4 receptor (IL-4RA Ex5+14A>G, IL-4RA Ex11+828A>G) considered singly or as haplotypes, are correlated with H. pylori virulence genes or H. pylori associated diseases. We studied 144 patients with non-cardia gastric cancer (NCGC)(41/50 with present or past H. pylori infection), 75 with duodenal ulcer (DU)(66 H. pylori infected) and 171 with gastritis (CG)(107 H. pylori infected). cagA gene was present in 24/28 NCGC, 45/59 DU and 56/107 CG. All SNPs were in Hardy-Weinberg equilibrium. IL-4RA haplotypes frequencies were estimated using Arlequin software. Neither the SNPs nor the IL-4RA haplotype correlated with disease diagnosis, H. pylori infection, degree of mucosal inflammation or intestinal metaplasia. IL-4 -588T allele (OR=3.69, 95% CI:1.34-10.16) and IL-4RA GA haplotype (p<0.05) enhanced the risk for cagA positive infections. IL-4RA GA haplotype correlated with IL-4 protein levels in H. pylori infected gastric mucosa. IL-4 and IL-4RA gene polymorphisms concur in selecting the H. pylori infecting strain, prob...Continue Reading

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Citations

Apr 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li ZhenzhenSun Ning
Apr 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ZhangJianxin Lu
Mar 12, 2010·World Journal of Gastroenterology : WJG·Mitsushige SugimotoTakahisa Furuta
Sep 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zihan SunJing Pei
Jun 29, 2017·Molecular Medicine Reports·Yingxian JiaShangwei Li
Jan 17, 2021·International Journal of Molecular Sciences·Xujun SongMarko Kornmann

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