IL-4: an important cytokine in determining the fate of T cells

Biophysics Reviews
J L Silva-FilhoA A S Pinheiro

Abstract

The pleiotropic effect of cytokines has been well documented, but the effects triggered by unique cytokines in different T cell types are still under investigation. The most relevant findings on the influence of interleukin-4 (IL-4) on T cell activation, differentiation, proliferation, and survival of different T cell types are discussed in this review. The main aim of our study was to correlate the observed effect with the corresponding molecular mechanism induced on IL-4/IL-4R interaction, in an effort to understand how the same extracellular stimuli can trigger a wide spectrum of signaling pathways leading to different responses in each T cell type.

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Citations

Jun 4, 2019·Current Opinion in Allergy and Clinical Immunology·Lennart M RoesnerAnnice Heratizadeh
Mar 18, 2020·Animals : an Open Access Journal From MDPI·Elzbieta PietrzakAnna Slawinska
Jun 9, 2020·The Journal of Dermatological Treatment·Shelley K UppalJashin J Wu
Feb 13, 2018·Immunological Reviews·Ivana HalovaPetr Draber
Jan 18, 2020·Current Allergy and Asthma Reports·Andrew LongR Sharon Chinthrajah
Oct 21, 2020·Nature Reviews. Immunology·Mohamed A ElTanbouly, Randolph J Noelle
Mar 9, 2020·The Journal of Allergy and Clinical Immunology·Claus BachertOlga Krysko
Aug 4, 2021·Journal of Molecular and Cellular Cardiology·Samantha J PaddockCaitlin C O'Meara

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