IL-4 and IL-10 are essential for immunosuppression induced by high molecular weight proteins from Ascaris suum

Cytokine
Valdênia Maria Oliveira SouzaM S Macedo

Abstract

The extract from Ascaris suum worms (Asc) impairs Th1 and Th2 responses to a non-related antigen, i.e. ovalbumin (OVA). Its suppressive capacity is due to high molecular weight components present in a gel filtration fraction (PI). This fraction is able to elicit IL-4 and IL-10 secretion. Interestingly enough, it induces anti-PI non-anaphylactic IgG1 synthesis through the action of IL-12/IFN-gamma. Here, we investigated the down-regulation of the immune response to OVA by PI in IL-12, IFN-gamma, IL-4 or IL-10 C57BL/6 knockout mice immunized with OVA+PI in adjuvant. OVA-induced delayed-type hypersensitivity (DTH) reactions, secretion of IL-2 and IFN-gamma, and IgG1, IgG2c and IgE antibody production were suppressed by PI in wild-type mice, as well as in IL-12- or IFN-gamma-deficient mice. In contrast, PI had no effect on anti-OVA IgE production and DTH, and induced only a partial suppression of IgG1 and IFN-gamma in IL-10(-/-) mice. The experiments also showed that IL-4 was involved in the PI-induced suppression of IgG2c antibodies and IL-2 secretion. Finally, down-regulation of IFN-gamma was not seen in mice lacking both IL-4 and IL-10, i.e. IL-4(-/-) mice treated with anti-IL-10 antibodies before immunization. These results exc...Continue Reading

References

Jan 1, 1992·International Archives of Allergy and Immunology·M F SoaresM S Macedo
Aug 1, 1995·Current Opinion in Immunology·E J Pearce, S L Reiner
May 1, 1995·Cellular Immunology·A P FerreiraM S Macedo
Jul 1, 1995·The Journal of Experimental Medicine·D J BergD Rennick
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J K ActorJ A Berzofsky
Nov 1, 1993·European Journal of Immunology·F PowrieR L Coffman
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·N R LynchN Alvarez
Sep 1, 1993·European Journal of Immunology·F PowrieR L Coffman
Nov 20, 1998·Clinical and Experimental Immunology·E L Faquim-Mauro, M S Macedo
Sep 1, 1999·Clinical and Experimental Immunology·G R StewartJ E Bradley
Sep 29, 1999·Immunology Today·H Groux, F Powrie
Feb 15, 2000·Parasite Immunology·M NacherS Looareesuwan
Sep 9, 2000·The Journal of Infectious Diseases·P J CooperT B Nutman
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F CottrezH Groux
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C C WangD Abraham
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed Elfatih H BashirCathryn Nagler-Anderson
Oct 16, 2002·Infection and Immunity·Jacqueline C M PatersonCatherine E Lawrence
Oct 31, 2002·The Journal of Investigative Dermatology·Gabriele MüllerAlexander H Enk
Dec 28, 2002·International Immunology·Diane SewellZsuzsa Fabry
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C LimaM S Macedo
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnès BoitelleCatherine E Lawrence
Dec 1, 1960·Archives of Biochemistry and Biophysics·T ELLISONF M STRONG
Feb 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T M OshiroM F Macedo-Soares

❮ Previous
Next ❯

Citations

Jun 29, 2006·International Archives of Allergy and Immunology·Aldacilene S SilvaMahasti S Macedo
May 17, 2007·Current Allergy and Asthma Reports·Maria Fernanda de Macedo Soares, Mahasti Sahihi de Macedo
Jun 22, 2014·Parasitology Research·Wheverton C NascimentoValdênia O Souza
Nov 4, 2010·Scandinavian Journal of Immunology·C A A de AraújoM F Macedo-Soares
Aug 18, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Valdênia Maria Oliveira Souza, Mahasti Sahihi Macedo
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D M ItamiM F Macedo-Soares
Feb 16, 2021·Parasite Immunology·Roeckson Carlos Peixoto SilvaValdênia Maria Oliveira de Souza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Ascariasis (ASM)

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Ascariasis

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Related Papers

International Archives of Allergy and Immunology
Aldacilene S SilvaM S Macedo
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M S Macedo, J A Barbuto
© 2021 Meta ULC. All rights reserved