IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice

Immunity
Pascal LaunoisJ A Louis

Abstract

BALB/c mice develop aberrant T helper 2 (Th2) responses and suffer progressive disease after infection with Leishmania major. These outcomes depend on the production of interleukin-4 (IL-4) early after infection. Here we demonstrate that the burst of IL-4 mRNA, peaking in draining lymph nodes of BALB/c mice 16 hr after infection, occurs within CD4+ T cells that express V beta 4 V alpha 8 T cell receptors. In contrast to control and V beta 6-deficient BALB/c mice, V beta 4-deficient BALB/c mice were resistant to infection, demonstrating the role of these cells in Th2 development. The early IL-4 response was absent in these mice, and T helper 1 responses occurred following infection. Recombinant LACK antigen from L. major induced comparable IL-4 production in V beta 4 V alpha 8 CD4+ cells. Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of V beta 4 V alpha 8 CD4+ T cells after cognate interaction with a single antigen from this complex organism.

References

Jun 1, 1992·The Journal of Experimental Medicine·W HeldH Acha-Orbea
Dec 1, 1995·The Journal of Experimental Medicine·A Bendelac
Apr 28, 1995·Science·E MougneauN Glaichenhaus
Feb 1, 1995·The Journal of Experimental Medicine·C S HsiehK M Murphy
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
Sep 27, 1993·Journal of Immunological Methods·S L ReinerR M Locksley
Mar 5, 1993·Science·S L ReinerR M Locksley
May 1, 1996·European Journal of Immunology·I MaillardH Diggelmann
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D GorhamK M Murphy
Sep 1, 1996·The Journal of Experimental Medicine·M KopfW Solbach

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Citations

Dec 13, 2006·Clinical & Developmental Immunology·Nelson M VazClaudia R Carvalho
Jul 14, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D J Fowell, R M Locksley
Mar 31, 2005·Microbial Pathogenesis·Mary E WilsonRichard D Pearson
Mar 21, 1998·International Journal for Parasitology·C Bogdan, M Röllinghoff
Nov 11, 1999·Journal of Immunological Methods·G K DeKrey, R G Titus
Nov 24, 1999·Immunology Today·S J McSorley, P Garside
Jun 29, 2002·Current Opinion in Immunology·Martin F Bachmann, Manfred Kopf
Sep 2, 1998·Current Opinion in Immunology·J LouisP Launois
May 29, 1998·Current Opinion in Immunology·K M Murphy
Aug 28, 2002·Immunity·Daniel B StetsonRichard M Locksley
Feb 6, 2007·Parasitology·L KedzierskiE Handman
Sep 24, 2004·Nature·Roberto A MaldonadoLaurie H Glimcher
Mar 22, 2002·Nature Reviews. Immunology·Foo Y Liew
Dec 12, 2001·Parasite Immunology·L M BagenstoseM Monestier
Aug 24, 1999·Immunology and Cell Biology·N L Harris, F Ronchese
Jun 2, 1998·Kidney International·C J KellyD P Gold
Oct 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kiri HonmaKatsuyuki Yui
Dec 22, 1998·The Journal of Experimental Medicine·M BixR M Locksley
Nov 6, 1998·The Journal of Experimental Medicine·A E WakilR M Locksley
Apr 6, 1999·The Journal of Experimental Medicine·S PingelR M Locksley
Jun 5, 2002·The Journal of Experimental Medicine·Leonid GorelikRichard A Flavell
Dec 6, 2003·The Journal of Experimental Medicine·Ben L KellyRichard M Locksley
Jan 16, 2008·International Immunology·Kazutomo SuzueShigeo Koyasu

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