PMID: 8941674Dec 1, 1996Paper

IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts

The Journal of Investigative Dermatology
H A MakhlufM Trojanowska

Abstract

Tenascin (TN), a large extracellular matrix glycoprotein, is transiently expressed during embryonic development, but is absent from most normal adult tissues. TN is reexpressed, however, in healing wounds, in the stroma of some tumors, and in fibrotic diseases such as systemic sclerosis (SSc) and rheumatoid arthritis. To clarify the mechanisms regulating TN expression, we studied the effects of selected cytokines (PDGF, bFGF, TGF-beta, IL-1, IL-4, IL-6, IFN-gamma, and TNF-alpha) found in fibrotic tissue on TN expression by dermal fibroblasts. IL-4 strongly induced TN protein levels (up to 10-fold over the basal level), whereas PDGF and bFGF were less potent inducers of TN than IL-4. All other cytokines tested, including TGF-alpha1, did not stimulate TN synthesis. IL-4 also increased TN mRNA expression, and this effect was blocked by actinomycin D. Cycloheximide increased basal TN mRNA expression and induced TN mRNA in IL-4-treated fibroblasts, suggesting that repressor protein(s) may regulate transcription of the TN gene. Although no differences in constitutive TN expression or effects of cytokines on TN expression were observed between SSc and healthy fibroblasts, these data are consistent with the observations that high level...Continue Reading

References

Oct 1, 1992·Arthritis and Rheumatism·S S McCachren, V A Lightner
Oct 1, 1992·The British Journal of Dermatology·J P LacourJ P Ortonne
Jan 1, 1989·Annual Review of Cell Biology·H P Erickson, M A Bourdon
Dec 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W J Rettig, P Garin-Chesa
Oct 1, 1994·Current Opinion in Cell Biology·J Gailit, R A Clark
Jan 1, 1995·International Reviews of Immunology·B L Gruber
Sep 1, 1993·British Journal of Rheumatology·D M Salter
Jul 1, 1994·Clinics in Dermatology·D M Fagundus, E C Leroy

❮ Previous
Next ❯

Citations

Jun 25, 1998·The American Journal of Physiology·Y ZhaoJ C McIntosh
Nov 8, 2001·Plastic and Reconstructive Surgery·V K Rumalla, G L Borah
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hironobu IhnKunihiko Tamaki
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·François HuauxSem H Phan
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Feb 24, 2010·The Journal of Dermatology·Toshiyuki Yamamoto
Jan 6, 2011·Respiratory Research·Anna MeuronenHarri Alenius
May 12, 2011·Head and Neck Pathology·Apostolos EpivatianosAnastasios Markopoulos
Jun 6, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ayan ChatterjeeDouglas J Rhee
Jul 5, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·José Cisneros-LiraAnnie Pardo
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka NakamuraNizar N Jarjour
Sep 13, 2008·Clinical and Experimental Pharmacology & Physiology·Xiao-Hong ChenNan-Shan Zhong
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Rie SugimotoHajime Nawata
Aug 23, 2011·Current Opinion in Rheumatology·Frédéric BatteuxAmélie Servettaz
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiangde LiuStephen I Rennard
Nov 19, 2003·The Journal of Experimental Medicine·Thomas SchülerThomas Blankenstein
Mar 10, 2010·Expert Opinion on Pharmacotherapy·Arnold E PostlethwaiteTitilola Akhigbe
Nov 26, 2010·Annual Review of Pathology·Tamiko R KatsumotoM Kari Connolly
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei P AtamasBarbara White
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia JakubzickCory M Hogaboam
Feb 1, 2005·Experimental Dermatology·Toshiyuki Yamamoto, Kiyoshi Nishioka
Jan 13, 2006·Archives of Dermatological Research·Toshiyuki Yamamoto
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon PhippsA Barry Kay
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Elizabeth Gore-HyerMaria Trojanowska
Mar 24, 2021·Neurorehabilitation and Neural Repair·John M DainesMatthew D Wood
Sep 3, 1999·Clinical and Diagnostic Laboratory Immunology·S P Atamas, B White
Sep 28, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·M A LatijnhouwersJ Schalkwijk
Jul 27, 2005·Journal of Dermatological Science·Kaoru OgawaChisei Ra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Investigative Ophthalmology & Visual Science
A MatsudaM Kusakabe
The Journal of Immunology : Official Journal of the American Association of Immunologists
T J Hemesath, K Stefansson
© 2021 Meta ULC. All rights reserved