IL-5 in the plasma-cell-dominant Castleman disease: a nosological entity

Oxford Medical Case Reports
Hans Raj PahadiyaManoj Lakhotia

Abstract

A 40-year-old male presented with a history of low-grade fever, weight loss, night sweats and breathlessness of 3 months duration. On examination, the patient had freely mobile lump in left lumbar region. The lump was surgically excised. Histological examination and immunohistochemistry of the specimen were consistent with the diagnosis of plasma cell variant of the Castleman disease. The patient had polyclonal hypergammaglobulinemia, anemia, eosinophilia and elevated interleukin (IL)-6 level. The level of IL-5 was not measured; however, the presence of eosinophilia indirectly suggests an increased IL-5 level. He obtained complete remission after resection of lump and 20 months of surgery had no signs and symptoms of diseases recurrence with normal hematological parameters. We discuss the role of IL-5 in the pathophysiology of the Castleman disease along with dysregulated overproduction of IL-6.

References

Oct 13, 2009·International Immunology·Taku Kouro, Kiyoshi Takatsu
Feb 19, 2010·The Gulf Journal of Oncology·A M Al-AmriK Q Ghallab
Oct 14, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Jacob D SoumeraiJeremy S Abramson

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Citations

Jan 26, 2021·Journal of Ophthalmology·Dongping LiFengyuan Sun

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Methods Mentioned

BETA
electrophoresis
X-ray
surgical resection

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