IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease

Genetics and Molecular Research : GMR
L LiT Wang

Abstract

We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain reaction restriction fragment length polymorphism assay. The CAD patients were more likely to be cigarette smokers, have a history of hypertension, have a higher value of total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and have a lower value of high-density lipoprotein cholesterol. Conditional logistic regression analyses showed that the CC genotype of IL-6-174G/C was significantly associated with increased risk of CAD [odds ratio (OR) = 2.99, 95% confidence interval (95%CI) = 1.56-6.00]. Moreover, the GG genotype of IL-6-572C/G was correlated with increased risk of CAD (OR = 1.99, 95%CI = 1.25-3.19). We found that IL-6-174G/C and IL-6-572C/G gene polymorphisms are associated with an increased risk of CAD.

Citations

Sep 20, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Haixia ZhangXiaodong Zhou
May 7, 2020·Journal of Cellular and Molecular Medicine·Shuai LuZhaohui Wang
Jul 29, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samira TabaeiSeyedeh Samaneh Tabaee
May 17, 2019·Indian Journal of Clinical Biochemistry : IJCB·Bobbala IndumathiVijay Kumar Kutala
Dec 29, 2020·International Journal of Cardiology·Agnieszka JabłońskaIhor Huk
Jan 14, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Nader SalariAliakbar Vaisi-Raygani
Oct 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Himanshu RaiRobert A Byrne

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