IL-6, TNFalpha and TGFbeta promote nonapoptotic trophoblast deportation and subsequently causes endothelial cell activation

Placenta
L M ChenLawrence W Chamley

Abstract

Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Failed transformation of the uterine spiral arteries leading to release of ischemic placental factors into the maternal circulation is thought to be the initial step in triggering preeclampsia. One placental factor associated with preeclampsia is necrotic trophoblastic debris that is deported in the maternal blood. The deported material ranges from multinucleated syncytial knots to nano-meter scale exosomes. Increasingly, it is being questioned whether failed transformation of the spiral arteries with subsequent placental ischemia is either necessary, or adequate, to explain the genesis of preeclampsia. In clinically established preeclampsia, maternal circulating levels of cytokines, such as TGFbeta, IL-6 and TNFalpha, are reported to be elevated. This study investigates whether cytokines can increase the shedding of necrotic material from the placenta. To investigate this question, placental explants were treated with nine cytokines which resulted in significantly increased amounts of trophoblasts being shed from explants treated with IL-6, TGFbeta-1 or TNFalpha but not the other cytokines. Trophoblast...Continue Reading

References

Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Apr 1, 1967·The Journal of Pathology and Bacteriology·W B RobertsonH G Dixon
Aug 1, 1961·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H D ATTWOOD, W W PARK
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Jul 14, 2006·American Journal of Reproductive Immunology : AJRI·Patrizia LuppiJulie A DeLoia
Sep 22, 2006·Molecular Human Reproduction·M H AbumareeL W Chamley
May 8, 2007·Journal of Reproductive Immunology·C W G Redman, I L Sargent
Dec 17, 2008·Placenta·J M Roberts, C A Hubel

❮ Previous
Next ❯

Citations

Mar 14, 2013·Bulletin of Experimental Biology and Medicine·O I StepanovaS A Selkov
Dec 10, 2013·Bulletin of Experimental Biology and Medicine·O I StepanovaS A Sel'kov
Nov 19, 2013·Placenta·L W ChamleyM Abumaree
Jan 21, 2012·Biology of Reproduction·Wu-Xiang LiaoDong-Bao Chen
Jul 24, 2012·Journal of Reproductive Immunology·Jelmer R PrinsSarah A Robertson
Feb 22, 2011·Journal of Reproductive Immunology·L W ChamleyM Abumaree
Jun 1, 2011·American Journal of Reproductive Immunology : AJRI·Michail KalinderisBasil C Tarlatzis
Mar 10, 2011·American Journal of Reproductive Immunology : AJRI·Jennifer A RoseJoan K Riley
Jun 25, 2013·American Journal of Reproductive Immunology : AJRI·Sien Yee LauLawrence W Chamley
Sep 22, 2015·Bulletin of Experimental Biology and Medicine·D I SokolovS A Sel'kov
Mar 22, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Simone Correa-SilvaEstela Bevilacqua
Apr 1, 2015·DNA and Cell Biology·Ilona HromadnikovaLadislav Krofta
Mar 15, 2015·The American Journal of Pathology·Monika SiwetzMartin Gauster
Aug 1, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·Y YangR Zhou
Sep 29, 2015·Reproduction, Fertility, and Development·Mary FamilariStefan R Hansson
Jul 28, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Akin UstaErtan Adali
Sep 29, 2018·American Journal of Reproductive Immunology : AJRI·Ioannis BellosCharalampos Siristatidis
Jun 5, 2010·Journal of Occupational and Environmental Medicine·Kristine KrajnakMichael L Kashon
Jan 23, 2019·Journal of Clinical Laboratory Analysis·Ruby AggarwalGayatri Rath
Jul 17, 2014·Archives of Gynecology and Obstetrics·Johannes StubertVolker Briese
Jan 8, 2019·American Journal of Reproductive Immunology : AJRI·Yan-Ran ShengXiao-Yong Zhu
Sep 19, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dmitry O BazhenovDmitry I Sokolov
Feb 6, 2016·Clinical Science·Ashlyn C HarmonBabbette LaMarca
Dec 12, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dmitriy BazhenovDmitriy Sokolov
Apr 3, 2021·American Journal of Physiology. Heart and Circulatory Physiology·María M PereiraDaniel Bia
Apr 4, 2021·Antioxidants·Xiang-Qun Hu, Lubo Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.