IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer

Tumori
Hassan YousefiArdeshir Ghavamzadeh

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, the majority of patients have chemoresistant disease. There is no treatment strategy with proven efficacy against chemoresistant EOC and in this setting, overcoming therapy resistance is the key to successful treatment. This study aimed to investigate expression of interleukin-6 (IL-6) (IL-6) and IL-6 receptor (IL-6R) in a panel of the EOC cell lines. To achieve this, the expression of IL-6 and its receptor were compared in the EOC cells using quantitative reverse transcription polymerase chain reaction. MTT assay was performed to obtain chemosensitivity of the EOC cells. In this report, we show that expressions of IL6 and IL6R are higher in therapy-resistant EOC cells compared to sensitive ones. Higher expression of IL6 and its receptor correlated with resistance to certain chemotherapeutic agents. Moreover, our findings showed that combination of tocilizumab (Actemra; Roche), an anti-IL-6R monoclonal antibody, with carboplatin synergistically inhibited growth and proliferation of the EOC cells and the most direct axis for IL-6 gene expression was NF-κB pathway. Collectively, our findings s...Continue Reading

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Citations

Jul 15, 2020·Iranian Biomedical Journal·Arash PoursheikhaniGhaffari Seyed H
Aug 20, 2019·Pathology Oncology Research : POR·Raffaella Mormile
Jul 28, 2019·Archives of Gynecology and Obstetrics·Raffaella Mormile
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Mar 28, 2021·Pesticide Biochemistry and Physiology·Jiyeon HamGwonhwa Song
Oct 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yingying SunDadao Jing

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