IL-7 effect on immunological reconstitution after HSCT depends on MHC incompatibility

British Journal of Haematology
Isabelle André-SchmutzM Cavazzana-Calvo

Abstract

Considerable progress has been recently accomplished in the management of patients who have undergone haplo-incompatible haematopoietic stem cell transplantation (HSCT) in terms of intake and prevention of graft-versus-host disease. Nevertheless haplo-incompatible HSCT is a procedure limited to a small number of patients because of the long-lasting immunodeficiency that is responsible for more than 50% of deaths within the first 3 months. Interleukin (IL)-7, which plays a unique and key role in T-cell development both in the mouse and in the human, is particularly attractive for attempting to speed up T-cell reconstitution. However, controversial results have been obtained after bone marrow graft in murine and primate models. To elucidate the impact of IL-7 treatment, we have performed HSCT in irradiated murine recombination activating gene (RAG) immunodeficient recipients, using donors that exhibited increased major histocompatibilty complex (MHC) incompatibility. Although irradiation performed prior to HSCT lead to a profound defect in the thymic stromal cells responsible for IL-7 production, IL-7 treatment had no significant effect on immune reconstitution in the MHC compatible and partially compatible settings. Interestingl...Continue Reading

References

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Citations

Feb 2, 2006·Cancer Immunology, Immunotherapy : CII·Ali Abdul-HaiReuven Or
Nov 27, 2008·Immunologic Research·Isabelle André-SchmutzMarina Cavazzana-Calvo
Sep 22, 2009·Current Opinion in Immunology·Marina Cavazzana-CalvoAlain Fischer
Jul 17, 2007·Comptes rendus biologies·Marina Cavazzana-CalvoAlain Fischer
Jan 22, 2005·Immunological Reviews·Alain FischerMarina Cavazzana-Calvo
Dec 13, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paolo SportolettiMauro Di Ianni
Nov 8, 2006·Current Opinion in Allergy and Clinical Immunology·Luigi D NotarangeloEvelina Mazzolari

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