PMID: 7544247Aug 1, 1995Paper

IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp)

Clinical and Experimental Immunology
Guido FerrariK J Weinhold

Abstract

CD8+ cytotoxic T lymphocytes are an important component in the immunologic control of human viral diseases. IL-7, a stromal cell-derived cytokine, has been demonstrated to enhance both anti-tumour and anti-viral CTL as well as lymphokine-activated killer (LAK) activity. We studied the ability of IL-7 to support the activation and the growth of in vitro antigen-specific CTL precursors (CTLp) present in peripheral blood mononuclear cells (PBMC) from HIV-infected patients. Results from these studies demonstrate that inclusion of IL-7 in a vaccinia/HIV-1 vector-based stimulation strategy greatly augmented overall CTL reactivities, whereas addition of IL-7 to unstimulated cultures failed to induce any significant anti-viral cytolytic activity. In four of six patients, HIV-specific lytic activities were significantly higher in cultures stimulated with antigen plus IL-7 compared with in vitro stimulation (IVS) with antigen alone. Cytotoxic activity was principally mediated by CD8+ effector cells, and CD3+/CD8+ cell expansion was increased by 2.7-fold in the presence of IL-7. In PBMC from seronegative donors, IL-7 enhanced anti-vaccinia CTL activities with less effect on cell proliferation. Furthermore, anti-gag CTL frequencies determi...Continue Reading

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Citations

Aug 25, 2011·Immunology and Cell Biology·Angela M Crawley, Jonathan B Angel
Jan 17, 2009·International Immunology·Elliott FallerPaul Macpherson
Nov 16, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nina D RussellUNKNOWN National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
Jun 30, 2012·Cytokine & Growth Factor Reviews·Morgan A ReuterMichael R Betts
Mar 17, 2012·Seminars in Immunology·Angela M Crawley, Jonathan B Angel
Feb 27, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Betty LiKarin Jooss
Oct 19, 2004·Molecular Immunology·Massimo Alfano, Guido Poli
Jun 25, 2013·FEMS Microbiology Reviews·Mariya I PetrovaSarah Lebeer
Sep 10, 2003·Antiviral Chemistry & Chemotherapy·K Kedzierska, S M Crowe
Mar 28, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sai LiuYonghong Zhang
Sep 13, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elliott M FallerPaul A MacPherson
Aug 28, 2001·AIDS Research and Human Retroviruses·G J GorseUNKNOWN National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
Jul 13, 2006·AIDS Research and Human Retroviruses·M J MulliganUNKNOWN NIH/NIAID/DAIDS HIV Vaccine Trials Network
Aug 19, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farley CleghornUNKNOWN 026 Protocol Team and the NIAID HIV Vaccine Trials Network
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A OstrowskiA S Fauci
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Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido FerrariKent J Weinhold
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey L KinterAnthony S Fauci

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