IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells

Journal of Autoimmunity
Stefano SammicheliBence Rethi

Abstract

Interleukin-7 (IL-7) promotes the maintenance and activation of peripheral T cells, whereas it does not act directly on mature B cells due to the lack of IL-7Rα expression on these. We report here that, in spite of the insensitivity of B cells to IL-7, high concentration of IL-7 can lead to increased B cell survival and antibody production in the presence of T cells, without the use of any further B cell stimulatory signal. IL-7 promoted B cell activation through inducing CD70 expression on resting T cells, particularly on CD4+ memory cells. The interaction of CD70 molecules with the B cell costimulatory receptor CD27 led to B cell proliferation, the accumulation of CD38 + CD20- plasmablasts and antibody production. In addition, IL-7 treatment induced BAFF secretion from resting peripheral T cells thereby promoting B cell survival. IL-7 levels can increase in lymphopenic conditions, in autoimmune diseases or in patients receiving T cell regenerative IL-7 therapy. Based on our findings high IL-7 levels can lead to increased B cell activation by inducing the B cell regulatory proteins CD70 and BAFF in resting T cells. Such activity might be beneficial in short term immune-stimulatory IL-7 therapies; permanently increased IL-7 lev...Continue Reading

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Citations

Jul 12, 2013·Clinical Reviews in Allergy & Immunology·Carlo SelmiPier Luigi Meroni
Feb 5, 2014·Journal of Autoimmunity·Christopher Chang
Aug 6, 2013·Journal of Autoimmunity·M Eric Gershwin, Yehuda Shoenfeld
Apr 19, 2013·AIDS·Sylvie AmuFrancesca Chiodi
May 6, 2017·Frontiers in Immunology·Francesca ChiodiAikaterini Nasi

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