IL-9 expression contributes to the cellular composition in Hodgkin lymphoma

European Journal of Haematology
I GlimeliusD Molin

Abstract

The presence of numerous mast cells or eosinophils in Hodgkin lymphoma (HL) tumours have both been described as negative prognostic factors. One cytokine related to HL is interleukin-9 (IL-9) and it is known to affect both mast cells and eosinophils. The aim of this study was to explore if the expression of IL-9 correlates to the presence of these inflammatory cells in HL tumours. In 131 HL biopsies, immunostainings for IL-9 and IL-9 receptor (IL-9R) were performed. The same material was previously stained for mast cells and eosinophils. These data were correlated to clinical and survival data from all patients. Fifty-three percent of cases were positive for IL-9 and 19% were positive for IL-9R in the cytoplasm of the tumour cells. The IL-9 positive patients had more eosinophils (P = 0.002) and mast cells (P = 0.02) in their tumours, more often a nodular sclerosis histology (P < 0.0001), a higher white-blood-cell count (P = 0.006) and a higher erythrocyte sedimentation rate (P = 0.003) at the time of diagnosis. IL-9 expression is related to the histology, clinical picture and the presence of eosinophils and mast cells in HL. These results indicate that IL-9 is an important part of the cytokine network and inflammatory infiltrat...Continue Reading

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Citations

Jul 23, 2013·Seminars in Cancer Biology·Yuxuan LiuAnke van den Berg
Oct 30, 2013·Leukemia & Lymphoma·Francesco GaudioGiorgina Specchia
Nov 7, 2012·Leukemia & Lymphoma·Xiao Lv, Xin Wang
Nov 20, 2008·Journal of Internal Medicine·D de Jong, G Enblad
Mar 1, 2015·Seminars in Cancer Biology·Eri Matsuki, Anas Younes
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian SteidlRandy D Gascoyne
Nov 6, 2018·Journal of Leukocyte Biology·Dounia ChraaAbdallah Badou
Jun 9, 2020·Frontiers in Immunology·Tao ChenZhaoming Ye
Apr 17, 2017·Allergologia et immunopathologia·A Tak ManeshA Aghamohammadi

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