IL12p40 regulates functional development of human CD4+ T cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases

Medicine
Xiaobing WangBing Xia

Abstract

The proinflammatory effects of IL12p40 had been documented in the literature, and anti-IL12p40 treatment had been proved to be effective in therapy of Crohn disease (CD) in a phase 2b clinical trial. However, the precise role of IL12p40 in the pathogenesis of inflammatory bowel disease (IBD) was still poorly understood. In this study, we investigated the expressions of IL12p40 and its receptor interleukin-12 receptor β 1 both locally and systemically in IBD cases and healthy controls, and the contribution of IL12p40 in IBD pathogenesis. We found that the expression of IL12p40 was elevated both at messenger RNA and protein levels systematically and locally in IBD patients but more significantly in CD patients. Our genetic association study revealed that the polymorphisms of IL12B rs6887695 were associated with both CD and ulcerative colitis (UC) susceptibility in Chinese population, but did not affect the serum IL12p40 level in either CD patients or UC patients. In addition, CD4⁺ T cells isolated from peripheral blood of CD patients secreted the most abundant IL12p40 production, compared with the UC patients and healthy controls. We also found for the first time that neutralizing IL12p40 secretion could inhibit proliferation, en...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Oct 15, 1998·Gut·R S WalmsleyR N Allan
Jan 10, 2002·Gastroenterology·David M SpencerAlan D Levine
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Apr 8, 2003·Scandinavian Journal of Gastroenterology·O H NielsenB Vainer
Nov 18, 2004·Immunological Reviews·Claire L LangrishDaniel J Cua
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eiko ToichiKevin D Cooper
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Apr 3, 2008·Inflammatory Bowel Diseases·Ana MárquezAlfonso Martínez
Feb 25, 2009·Inflammatory Bowel Diseases·Dermot P B McGovernKent D Taylor
Apr 14, 2009·Trends in Molecular Medicine·Lauren A ZenewiczRichard A Flavell
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuyoshi UtsugiMasatomo Mori
Mar 1, 2008·Journal of Crohn's & Colitis·E F StangeUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Feb 26, 2011·Inflammatory Bowel Diseases·A SzperlC C van Diemen
May 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ting FengYingzi Cong
May 10, 2011·BMC Medical Genetics·Inga PeterUNKNOWN New York Crohn's Disease Working Group
Jun 17, 2011·Nature·Kevin J Maloy, Fiona Powrie
Apr 6, 2012·PloS One·Jürgen GlasStephan Brand
Oct 19, 2012·The New England Journal of Medicine·William J SandbornUNKNOWN CERTIFI Study Group
Apr 12, 2013·Journal of Gastroenterology and Hepatology·Chang Mo MoonJae Hee Cheon
Dec 19, 2013·PloS One·Elena PettiniDonata Medaglini
Feb 27, 2014·BMC Infectious Diseases·Daniel Rodriguez-PintoDiane McMahon-Pratt

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
ELISA
PCR
genotyping
flow cytometry

Software Mentioned

Quantity One
Multicycle
Statistical Product and Service Solutions ( SPSS Vision

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