IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study

Respiratory Research
A SadeghnejadS Ewart

Abstract

Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. In the Isle of Wight birth cohort (UK, 1989-1999), five IL13 single nucleotide polymorphisms (SNPs): rs1800925 (-1112C/T), rs2066960, rs1295686, rs20541 (R130Q) and rs1295685 were genotyped. Parents were asked whether their children had wheezed in the last 12 months at ages 1, 2, 4 and 10 years. Children who reported wheeze in the first 4 years of life and also had wheezing at age 10 were classified as early-onset persistent wheeze phenotype; non-wheezers never wheezed up to age 10. Persistent asthma was defined as having a diagnosis of asthma both during the first four years of life and at age 10. Logistic regression methods were used to analyze data on 791 children with complete information. Potential confounders were gender, birth weight, duration of breast feeding, and household cat or dog present during pregnancy. Maternal smoking during pregnancy was associated with early-onset persistent wheeze (OR 2.93, p < 0.0001); polymorphisms in IL13 were not (OR 1.15, p ...Continue Reading

References

May 1, 1992·The American Review of Respiratory Disease·J P HanrahanF E Speizer
Dec 1, 1966·Genetical Research·W G Hill, A Robertson
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·A F HooJ Stocks
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
May 18, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·A D MilnerC Susiva
Feb 24, 2001·Genes and Immunity·T C van der Pouw KraanJ S van der Zee
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·Z WangX Xu
Jun 5, 2001·Current Opinion in Pediatrics·H Hakonarson, M Wjst
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·T D HowardE R Bleecker
Oct 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T F LeungC W Lam
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G DevereuxA Seaton
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Vercelli
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Susan ColillaUNKNOWN Collaborative Study for the Genetics of Asthma
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J KurukulaaratchyS H Arshad
Sep 27, 2003·Allergy·P S NoakesS L Prescott
Dec 4, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·T HummelshojA Svejgaard
Jan 10, 2004·American Journal of Public Health·Jouni J K Jaakkola, Mika Gissler
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Sabine HoffjanCarole Ober
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jun 4, 2005·Genes and Immunity·J N WilsonD Kwiatkowski
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Deborah A MeyersEugene R Bleecker
Sep 29, 2005·Acta Paediatrica·Ramesh J KurukulaaratchySayed H Arshad
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Wojciech FeleszkoMarek Kulus
Jan 3, 2006·The Journal of Infectious Diseases·Beena PuthothuAndrea Heinzmann
Feb 18, 2006·American Journal of Respiratory and Critical Care Medicine·Hanns MoshammerTony Fletcher
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa CameronDonata Vercelli
Mar 10, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Alireza SadeghnejadSusan Ewart
Jul 7, 2007·American Journal of Respiratory and Critical Care Medicine·Alireza SadeghnejadJill A Ohar
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ulrike PetersCharles B Foster

❮ Previous
Next ❯

Citations

Nov 5, 2008·Annual Review of Public Health·Stephanie J London, Isabelle Romieu
Apr 7, 2012·Clinical & Developmental Immunology·Jen-Chieh ChangChieh-An Liu
Apr 21, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ikechukwu U OgbuanuSyed H Arshad
May 13, 2009·Emerging Themes in Epidemiology·Ikechukwu U OgbuanuWilfried Karmaus
Feb 6, 2013·PloS One·Ching-Hui TsaiYungling Leo Lee
Mar 8, 2012·Chest·Saeher A F Muzaffar, David C Christiani
Apr 21, 2012·The Journal of Pain : Official Journal of the American Pain Society·Birha McCannBradley E Aouizerat
May 18, 2011·Reproductive Toxicology·Rodney R Dietert
Mar 18, 2011·The Journal of Allergy and Clinical Immunology·Olga E SavenijeMarjan Kerkhof
Jul 27, 2010·Seminars in Perinatology·T Michael O'SheaCaroline Signore
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Erika von Mutius
Jun 26, 2009·The Journal of Investigative Dermatology·Kristina Callis DuffinGerald G Krueger
Mar 22, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chien-Han ChenWei J Chen
Apr 27, 2010·Dermatologic Therapy·Kristina Callis DuffinGerald G Krueger
Feb 12, 2010·Annals of the New York Academy of Sciences·Loralyn A Benoit, Michael J Holtzman
Jan 25, 2012·Clinical & Developmental Immunology·Chih-Chiang WuHo-Chang Kuo
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Jean BousquetPeter J Gergen
May 27, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gabrielle A LockettJohn W Holloway
Jan 22, 2014·The Clinical Respiratory Journal·Niklas KahrSimon Francis Thomsen
Jul 11, 2013·BioMed Research International·Yongan LiuQingyu Xiu
Jan 11, 2011·Trends in Genetics : TIG·Carole Ober, Donata Vercelli
Oct 30, 2016·Paediatric Respiratory Reviews·Insa KortenPhilipp Latzin
Feb 25, 2017·Environmental Health : a Global Access Science Source·Edith B MilanziUlrike Gehring
Jan 26, 2018·Health Economics Review·Kerry BellUNKNOWN Building Blocks trial group
Mar 22, 2019·Current Opinion in Pediatrics·Benjamin A Raby
Nov 12, 2015·European Clinical Respiratory Journal·Simon F Thomsen
Aug 29, 2018·American Journal of Respiratory and Critical Care Medicine·Hooman MirzakhaniScott T Weiss
May 16, 2019·Current Opinion in Pediatrics·Benjamin A Raby
Jan 11, 2020·Frontiers in Pediatrics·Eva Morales, David Duffy
Mar 17, 2018·International Journal of Epidemiology·S Hasan ArshadRamesh Kurukulaaratchy
Aug 31, 2011·Cadernos de saúde pública·Decio MedeirosDirceu Solé
Sep 23, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·En Nee SchultzCatherine M Hayden
May 1, 2021·International Journal of Molecular Sciences·Ricardo G FigueiredoAlvaro A Cruz

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

STAT
SAS
SNPper
GLIMMIX
Haploview
PHASE

Related Concepts

Related Feeds

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved