IL18 signaling promotes homing of mature Tregs into the thymus.

ELife
Cristina Peligero-CruzJakub Abramson

Abstract

Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitute a major subset of yet poorly understood cells. Here we describe a subset of thymus recirculating IL18R+ Tregs with molecular characteristics highly reminiscent of tissue-resident effector Tregs. Moreover, we show that IL18R+ Tregs are endowed with higher capacity to populate the thymus than their IL18R- or IL18R-/- counterparts, highlighting the key role of IL18R in this process. Finally, we demonstrate that IL18 signaling is critical for the induction of the key thymus-homing chemokine receptor - CCR6 on Tregs. Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus.

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Citations

Dec 22, 2020·Frontiers in Immunology·Vera PlužarićStana Tokić
Feb 16, 2021·Frontiers in Immunology·Bram Van Den EeckhoutSarah Gerlo
Mar 2, 2021·Frontiers in Immunology·Jérémy C SantamariaMagali Irla
Apr 17, 2021·International Immunopharmacology·Huan-Rong LanXue Yang
Jun 22, 2021·International Reviews of Immunology·Kevin M HarrisLinda R Watkins
Aug 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Silvia Galván-PeñaChristophe Benoist

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Methods Mentioned

BETA
flow cytometry
FACS
flow-cytometry
RNAseq
X-ray
RNA-seq

Software Mentioned

Flow Jo
GraphPad Prism
DESeq2
UTAP

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