IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis

Gastroenterology
Dulciene Maria Magalhães QueirozCelso Affonso De Oliveira

Abstract

Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. The aim of this study was to evaluate whether carriers of these polymorphic genes are protected against gastroesophageal reflux disease (GERD). TNFA-308 polymorphisms were also studied. We prospectively evaluated 385 patients without gastric cancer and peptic ulcer. Of these patients, 383 (98 with GERD and 285 controls) were successfully genotyped for all cytokines studied. The cagA status of Helicobacter pylori isolates was determined by polymerase chain reaction (PCR). IL1B-511/-31, IL1RN, and TNFA-308 polymorphisms were genotyped by PCR, PCR/restriction fragment length polymorphism, or PCR/confronting 2-pair primers. Histologic gastritis was assessed according to the updated Sydney system. The role of the proinflammatory cytokine genotypes in the genesis of GERD was evaluated before and after stratification by H. pylori status in logistic regression models controlling for confounding factors. IL1B-31 (a near-complete linkage disequilibrium between polymorphism at -31 and -511 was found) and IL1RN*2 allele polymorphisms were associated with GERD. After strat...Continue Reading

References

May 1, 1992·Digestive Diseases and Sciences·F Mégraud, H Lamouliatte
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Mar 31, 1998·Scandinavian Journal of Immunology·S SanttilaM Hurme
Dec 24, 1998·Gut·H B el-Serag, A Sonnenberg
Apr 20, 2001·Journal of Microbiological Methods·L MonteiroF Mégraud
May 11, 2001·Japanese Journal of Cancer Research : Gann·N HamajimaS Tominaga
Aug 21, 2001·Gut·V J Warburton-TimmsC A McNulty
Aug 1, 2002·Journal of Clinical Microbiology·Dulciene Maria Magalhães QueirozAna Margarida Miguel Ferreira Nogueira
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Aug 2, 2003·Gastroenterology·José Carlos MachadoManuel Sobrinho-Simões

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Citations

Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Sep 29, 2006·Gut·Marília Campos Abreu MarinoDulciene Maria Magalhães Queiroz
Mar 2, 2013·PloS One·Dulciene Maria Magalhaes QueirozJean E Crabtree
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Sam M MbulaiteyeEmad M El-Omar
Dec 24, 2011·Gut and Liver·Nayoung KimUNKNOWN H. pylori and GERD Study Group of Korean College of Helicobacter and Upper Gastrointestinal Research
Aug 4, 2010·Journal of Neurogastroenterology and Motility·Uday C Ghoshal, Dipti Chourasia
Apr 26, 2015·The Kaohsiung Journal of Medical Sciences·Wen-Hung HsuChao-Hung Kuo
Nov 13, 2004·International Journal of Cancer. Journal International Du Cancer·Elvira Garza-GonzálezGuillermo Ignacio Pérez-Pérez
Jul 20, 2010·Gastroenterology·Mairi H McLean, Emad M El-Omar
May 20, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D McNamara, E El-Omar
Jan 2, 2008·Gastroenterology·Manuel R Amieva, Emad M El-Omar
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Paul Lochhead, Emad M El-Omar
Sep 24, 2005·Helicobacter·Limas Kupcinskas, Peter Malfertheiner
May 9, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R Canzi Almada de Souza, José Hermênio Cavalcante Lima
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Yi-Chia LeeMing-Shiang Wu
Jan 6, 2009·Journal of Gastroenterology and Hepatology·Justin C Y Wu
Jul 28, 2010·Journal of Gastroenterology and Hepatology·Hsin-Hung ChengWen-Ching Wang
Oct 2, 2012·Journal of Gastroenterology and Hepatology·Jin Joo KimHyun Chae Jung
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-C SuC-M Jan
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Emad M El-Omar
Feb 3, 2015·Gastroenterology Research and Practice·Su Jin Hong, Sang Woo Kim
Aug 31, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T Figueiredo SoaresD M M Queiroz
Sep 5, 2009·The Journal of Clinical Investigation·John C Atherton, Martin J Blaser
May 13, 2011·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Uday C Ghoshal, Dipti Chourasia
Oct 12, 2012·Molecular Biology Reports·Hugo SousaRui Medeiros
Sep 27, 2005·Pediatric Research·Dulciene Maria Magalhães QueirozAnfrisina Sales Teles Carvalho
Sep 17, 2019·Molecular Medicine Reports·Huan WangChanglong Lu
Jan 27, 2009·Journal of Clinical Gastroenterology·Ki-Nam ShimUNKNOWN H. pylori and GERD Study Group of Korean College of Helicobacter and Upper Gastrointestinal Research
Mar 27, 2009·World Journal of Gastroenterology : WJG·Hivana-Patricia Melo BarbosaTereza-Cristina de Oliveira Corvelo
Aug 27, 2011·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Justin C Y Wu
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·M Constanza CamargoBarbara G Schneider

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