IL1RN VNTR and IL2-330 polymorphic genes are independently associated with chronic immune thrombocytopenia

British Journal of Haematology
Andreia Maria Camargos RochaDulciene Maria Magalhães Queiroz

Abstract

Chronic Immune Thrombocytopenia (cITP) is an acquired immune-mediated disease associated with a T-helper cell type 1 (Th1) immune polarization, whose genetic risk factors, however, are largely unknown. We investigated polymorphisms in promoter regions of genes that code molecules involved in proinflammatory immune response [IL1B-31T/C, IL1RN variable number tandem repeats (VNTR), IL2-330T/G, and TNF-307G/A] as well as in genes that code Toll like receptors (TLR) (TLR2 Arg753Gln, TLR4 Asp299Gly and TLR5 Arg(392stop)) in 122 patients with cITP and 541 blood donors. The frequencies of the IL1RN polymorphic allele 2 (P = 0·001) and of the IL2-330 polymorphic allele G (P =0·004) were significantly higher in cITP patients than in blood donors. In logistic analysis adjusting for age and gender, the polymorphisms remained independently associated with cITP. Enhanced serum concentrations of interleukin (IL)-1α and IL-1β were observed in cITP (P < 10(-3) ) and blood donor (P = 0·04) carriers of the IL1RN*2. Also, the serum levels of IL-2 and γ-interferon (IFN-γ) were increased in cITP patients (P < 10(-3) and P = 0·04 respectively) and blood donors (P < 10(-3) and P = 0·03 respectively) harbouring the IL2-330G allele. Here we demonstrate...Continue Reading

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Citations

Apr 17, 2013·Journal of Hematology & Oncology·Andreia Maria Camargos RochaDulciene Maria Magalhães Queiroz
Mar 19, 2014·La Presse médicale·Douglas B CinesJohn W Semple
Nov 16, 2013·Neurocritical Care·Kyra J BeckerJonathan Weinstein
Apr 1, 2015·British Journal of Haematology·Quentin A Hill, Adrian C Newland
Sep 25, 2014·British Journal of Haematology·Hui ZhongKarina Yazdanbakhsh
Dec 14, 2016·Genetic Testing and Molecular Biomarkers·Jing ZhangXiao-Zhong Wang
Jun 28, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hadi RezaeeyanNajmaldin Saki
Jul 31, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Alaa Efat HassanMohamed Abdelhafez
Sep 26, 2017·Hematology·Marica PavkovicAleksandar Stojanovic
May 16, 2018·Frontiers in Immunology·Maurice SwinkelsA J Gerard Jansen

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