IL28B gene polymorphisms in mono- and HIV-coinfected chronic hepatitis C patients

Frontiers in Microbiology
Bruna C BertolPaulo H C de França

Abstract

Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the allelic and genotypic variants of the IL28B polymorphisms rs12979860 (C/T) and rs8099917 (T/G) and their possible association with the establishment of HCV infection. A total of 199 non-infected controls and 230 patients with chronic hepatitis C, including 53 coinfected with HIV, participated in the study. Genotyping consisted of polymerase chain reaction and subsequent analysis of the restriction patterns resulting from exposure to endonucleases. Among the controls with established results, 47.4% (90/190) exhibited the rs12979860 CC genotype, 43.7 CT, and 8.9% TT, whereas 29.1% (66/227), 51.5%, and 19.4% of the patients exhibited the CC, CT, and TT genotypes, respectively. With respect to rs8099917, 66.8% (133/199) of the controls exhibited the TT genotype, 31.2% TG, and 2.0% GG, whereas 56.1% (129/230), 40.9%, and 3.0% of the patients exhibited the T...Continue Reading

References

May 8, 2001·Revista Da Sociedade Brasileira De Medicina Tropical·E Strauss
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MartinoP Marcellin
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harald HoferPeter Ferenci
Apr 15, 2003·Clinics in Liver Disease·Leonard B Seeff, Jay H Hoofnagle
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Apr 23, 2004·Genes and Immunity·L J Yee
Jul 1, 2006·Revista de saúde pública·Anita Campos Mendonça Silva, Antônio Alci Barone
Mar 27, 2007·Revista de saúde pública·Luiz Alberto de Souza Ciorlia, Dirce Maria Trevisan Zanetta
Sep 15, 2009·Nature Genetics·Vijayaprakash SuppiahJacob George
Sep 18, 2009·Nature·David L ThomasMary Carrington
May 12, 2010·Expert Review of Anti-infective Therapy·Fumio ImazekiMasao Omata
Oct 19, 2010·Gastroenterology·Ashwin BalagopalChloe L Thio
Oct 28, 2010·The Journal of Infectious Diseases·Maureen P MartinChloe L Thio
Nov 30, 2010·Journal of Hepatology·Christoph SarrazinThomas Berg
Dec 15, 2010·Journal of Hepatology·Bettina LanghansUlrich Spengler
Jan 12, 2011·Current HIV/AIDS Reports·Eva A Operskalski, Andrea Kovacs
Mar 23, 2011·Gastroenterología y hepatología·Sabela Lens GarcíaXavier Forns Bernhardt
Apr 1, 2011·The New England Journal of Medicine·Fred PoordadUNKNOWN SPRINT-2 Investigators
Apr 1, 2011·The New England Journal of Medicine·Bruce R BaconUNKNOWN HCV RESPOND-2 Investigators
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Lourianne N CavalcanteAndré C Lyra
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Janett FischerThomas Berg
Jun 6, 2012·Journal of Virological Methods·Simone MoreiraPaulo Henrique Condeixa de França
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore Petta, Antonio Craxì
Dec 12, 2013·Journal of Gastroenterology and Hepatology·Kentaro MatsuuraYasuhito Tanaka
Apr 16, 2014·Hepatitis Monthly·Seyed Hossein Aalaei-AndabiliSeyed Moayed Alavian

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Citations

Sep 28, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Valéria Miranda AvanziSonia Mara Raboni

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BETA
genotyping
electrophoresis

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Epimax Table Calculator Strategies
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