IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients.

Journal of Gastroenterology
Mayu OhnishiKazuaki Chayama

Abstract

Several single nucleotide polymorphisms (SNPs) within the interleukin 28B (IL28B) locus are associated with sustained viral response in chronic hepatitis C (HCV) patients who were treated with pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy. Recently, an association between γ-GTP level and IL28B genotype was identified. In this study, the relationship between IL28B genotype and liver steatosis was analyzed. One hundred fifty-three patients who underwent liver biopsy before PEG-IFN plus RBV combination therapy were enrolled. The level of liver steatosis was measured using a BIOREVO BZ-9000 microscope, and the proportion of fatty change and clear cell change were calculated using Dynamic cell count BZ-H1C software. IL28B SNP genotype (rs8099917) was determined using the Invader Assay. Vesicular change was significantly associated with body mass index (BMI), HCV RNA titer, serum aspartate aminotransferase, γ-GTP, IL28B genotype and liver fibrosis level (P < 0.05). Clear cell change was significantly associated with serum aspartate aminotransferase, γ-GTP and IL28B genotype by univariate logistic regression analysis (P < 0.05). Under multiple logistic regression, IL28B genotype (OR(adj) = 8.158; 95% CI 2.412...Continue Reading

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Citations

Nov 14, 2013·World Journal of Gastroenterology : WJG·Mohammed EslamGolo Ahlenstiel
Aug 19, 2014·World Journal of Gastroenterology : WJG·Kamila WójcikAnna Piekarska
Jul 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K D WattM R Charlton
Sep 26, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andres Duarte-RojoMichael R Charlton
Jan 21, 2014·Journal of Viral Hepatitis·M A Jiménez-SousaS Resino
Mar 19, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromi KanKazuaki Chayama

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