IL2RA is associated with persistence of rheumatoid arthritis

Arthritis Research & Therapy
Hanna W van SteenbergenAnnette H M van der Helm-van Mil

Abstract

Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypothesized that variants associating with lack of radiographic progression also associate with DMARD-free sustained remission. 645 Dutch RA-patients were studied on DMARD-free sustained remission during a maximal follow-up duration of 10-years. Variants associated with radiographic progression under an additive model in the total RA-population (Human Leukocyte Antigens (HLA)-DRB1-shared epitope (SE), Dickkopf-1 (DKK1)-rs1896368, DKK1-rs1896367, DKK1-rs1528873, C5Orf30-rs26232, Interleukin-2 receptor-α (IL2RA)-rs2104286, Matrix metalloproteinase-9 (MMP-9)-rs11908352, rs451066 and Osteoprotegerin (OPG)-rs1485305) were studied. Cox-regression analyses were performed and Bonferroni correction applied. Soluble IL2Rα (sIL2Rα)-levels were studied. For replication, 622 RA-patients included in the French Evaluation et Suivi de POlyarthrites Indifférenciées Récentes cohort (ESPOIR)-cohort were investigated. Results were combined in invers...Continue Reading

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Citations

Dec 23, 2015·Assay and Drug Development Technologies·Hermann A M Mucke
Jun 25, 2016·International Journal of Molecular Sciences·Ill-Min ChungGovindasamy Rajakumar
Jul 12, 2019·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kenji TakahashiShinro Takai

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Methods Mentioned

BETA
genotyping
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS
Immunochip
STATA
KASPar
LightSnp

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