IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

PloS One
Antonio AlcinaFuencisla Matesanz

Abstract

IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and 927 matched Caucasian controls from the south of Spain. We observed association with MS in 6 of 8 SNPs. The rs1570538, at the 3'- UTR extreme of the gene, previously reported to have a weak association with MS, is replicated here (P = 0.032). The most associated T1D SNP (rs41295061) was not associated with MS in the present study. However, the rs35285258, belonging to another independent group of SNPs associated with T1D, showed the maximal association in this study but different risk allele. We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS. These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological rol...Continue Reading

References

Nov 14, 1985·Nature·P Newmark
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Sep 17, 1999·Neurology·A Karni, O Abramsky
Apr 17, 2002·Lancet·Alastair Compston, Alasdair Coles
Jul 27, 2004·American Journal of Human Genetics·Chieko KyogokuTimothy W Behrens
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Apr 6, 2005·American Journal of Medical Genetics. Part a·J William Lindsey
Sep 20, 2006·Nature Reviews. Genetics·David J Balding
Nov 30, 2006·Arthritis and Rheumatism·Blanca RuedaJavier Martín
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Catherine J OwenTony R Merriman
Mar 31, 2007·Diabetes·Hui-Qi QuConstantin Polychronakos
Apr 11, 2007·Journal of Neurology·Fuencisla MatesanzAntonio Alcina
Jun 15, 2007·Lancet Neurology·Sreeram Varadharajan RamagopalanUNKNOWN Canadian Collaborative Study Group
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 31, 2007·Nature Genetics·Simon G GregoryUNKNOWN Multiple Sclerosis Genetics Group
Nov 23, 2007·The New England Journal of Medicine·Sreeram V RamagopalanGeorge C Ebers
Jan 22, 2008·BMC Medical Genetics·Maristella PitzalisFrancesco Cucca
Jun 21, 2008·Lancet Neurology·UNKNOWN International Multiple Sclerosis Genetics Consortium (IMSGC)
Mar 29, 2011·Neurologic Clinics·Joseph P McElroy, Jorge R Oksenberg

❮ Previous
Next ❯

Citations

Nov 17, 2011·European Journal of Human Genetics : EJHG·Marie-Claude BabronFrançoise Clerget-Darpoux
Feb 25, 2011·Genes and Immunity·W S BushUNKNOWN International Multiple Sclerosis Genetics Consortium
Jul 21, 2009·PloS One·David OtaeguiAdolfo López de Munain
Feb 25, 2010·European Journal of Human Genetics : EJHG·María L CavanillasElena Urcelay
Nov 4, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Hanne F HarboAnne Spurkland
Aug 27, 2013·Genetic Testing and Molecular Biomarkers·Dorra BouzidHatem Masmoudi
Aug 3, 2013·Journal of Neurology·Agnès FromontThibault Moreau
Aug 6, 2011·The International Journal of Neuroscience·Abolghasem KollaeeMahdi Zamani
May 1, 2011·Expert Opinion on Medical Diagnostics·John W Rose, Noel G Carlson
Mar 29, 2011·Neurologic Clinics·Joseph P McElroy, Jorge R Oksenberg
May 11, 2010·Molecular and Cellular Probes·Sabine Hoffjan, Denis A Akkad
Nov 23, 2012·Clinical Endocrinology·Zhi-Yi SongHuai-Dong Song
Feb 9, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G K NikolopoulosP G Bagos
Apr 23, 2013·Clinical and Experimental Immunology·J B BollykyC J Greenbaum
Jan 15, 2015·European Journal of Human Genetics : EJHG·Claire Dandine-Roulland, Hervé Perdry
May 12, 2012·Autoimmune Diseases·Paola Cruz-TapiasJuan-Manuel Anaya
Oct 23, 2012·Journal of Autoimmunity·Owen NgalamikaQianjin Lu
Feb 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kevin GoudyRosa Bacchetta
Nov 20, 2012·Dermatologic Clinics·Ali JabbariAngela M Christiano
Dec 18, 2013·Journal of the Neurological Sciences·Gulibahaer AinidingUNKNOWN South Japan Multiple Sclerosis Genetics Consortium
Nov 29, 2011·The Journal of International Medical Research·L-M WangS-L Sun
Jan 18, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Marcelo MatielloOrhun H Kantarci
Aug 22, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter DurdaLeslie A Lange
Jan 29, 2020·Annual Review of Immunology·Peter A SavageChristine H Miller
Aug 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Michael Stolley, Daniel J Campbell
Dec 6, 2017·Journal of Endocrinological Investigation·N Pineda-TrujilloJ-M Alfaro
Nov 23, 2017·Frontiers in Immunology·Nicholas A J DawsonMegan K Levings
Jun 16, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O V ZaplakhovaO E Mustafina
Oct 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui-Qi QuConstantin Polychronakos
Nov 13, 2020·Reports of Biochemistry & Molecular Biology·Mohsen AsouriHaleh Akhavan-Niaki
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy

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