IL33 activates CD8+T and NK cells through MyD88 pathway to suppress the lung cancer cell growth in mice

Biotechnology Letters
Longsheng XuZhi-Ping Yang

Abstract

In this study, we observed the effects of IL-33 on tumor immune response in lung cancer-bearing mice using wild type and MyD88-/- mice respectively. Wild C57BL/6 (C57BL/6WT), MyD88 knockout C57BL/6 mice (C57BL/6 MyD88-/-) and Lewis cells were used in this study. Cell proliferation, cytokine release and cytotoxicity were detected. IL-33 could significantly up-regulate specific cellular immunity, inhibit tumor growth and improve survival time in wild type mice group, and it had dose dependent effect. However, IL-33 had no effect on cell immunity and tumor growth in MyD88-/- mice group. Compared with MyD88-/- mice, IL-33 could significantly increase the ratio of CD8+T cells to neutrophils in wild type mice, while the percentage of tumor infiltrating CD11b+ cells, Mo-MDSC, F4/80+ macrophages and mDC cells decreased significantly in wild type mice group. IL-33 could upregulate the expression of CD107a and IFN-γ in CD8+T cells and NK cells of wild type mice, while IL-33 could not upregulate them in MyD88-/- mice. IL-33 could upregulate the expression of CD40, CD80, CD86 and CD205 in DC cells in wild type mice, induce T cells to differentiate into Th1 cells and enhance tumor cell immunity. IL-33 could promote differentiation and matur...Continue Reading

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Citations

Nov 18, 2020·Bioengineered·Weiguo HuangYunfeng Shan
Dec 18, 2020·Frontiers in Immunology·Sara AndreoneFabrizio Mattei
Jun 17, 2021·European Journal of Immunology·Wenyi JiangYi Zhang

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Methods Mentioned

BETA
Assay
flow cytometry
PMA
electrophoresis

Software Mentioned

SPSS

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