Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2

International Journal of Biological Sciences
Wenhui ZhouCeshi Chen

Abstract

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, in TNBC has not been investigated, and the mechanisms remain elusive. Here, we demonstrated that Ilamycin-E, but not -F, decreases cell viability, inhibits G1/S cell cycle progression, and promotes apoptosis in the TNBC cell lines HCC1937 and MDA-MB-468. Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-induced apoptosis. These findings indicate that Ilamycin E has anti-cancer activity in TNBC.

Citations

Sep 8, 2019·International Journal of Molecular Sciences·Natalia SiweckaIreneusz Majsterek
Nov 11, 2020·Natural Product Reports·Jeffrey D RudolfZining Li
Feb 12, 2021·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
May 29, 2020·Seminars in Cancer Biology·Kah Keng Wong
Apr 6, 2021·World Journal of Biological Chemistry·Rama Rao MallaGanji Purnachandra Nagaraju
May 18, 2021·Chemistry & Biodiversity·Han ChenXiaoling Lu
May 21, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Linlin ZhangXiangxuan Zhao
Apr 24, 2020·Journal of Natural Products·Changli SunJunying Ma
Oct 12, 2021·Journal of Natural Products·Bin ZhouJames B McAlpine

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Datasets Mentioned

BETA
MDA-MB-231

Methods Mentioned

BETA
protein folding
Flow
Assay
transfection

Software Mentioned

SPSS
ImageQuant

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