ILC regulation of T cell responses in inflammatory diseases and cancer

Seminars in Immunology
Kathrin Warner, Pamela S Ohashi

Abstract

The tumor microenvironment is shaped by interactions between tumor cells, stroma, and immune cells. T cells are a critical component of the immunological anti-tumor response and most immunotherapeutic approaches in cancer aim to augment T cell responses. Recently, innate lymphoid cells (ILCs) have been added to the list of cell populations that influence T cell responses within the tumor microenvironment. ILCs were shown to modulate T cell functions through a variety of mechanisms. However, the impact of ILC and T cell interactions on disease outcome appears to be contextual as their phenotype and function is strongly influenced by the local tissue microenvironment. Here we focus on recent advances in understanding the mechanisms of ILCs in regulating T cell responses in inflammatory diseases and cancer.

Citations

Nov 5, 2019·Journal of Cellular Biochemistry·S Haleh HosseiniHamed Mohammadi
Feb 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Tian X ZhaoZiad Mallat
Feb 18, 2020·Frontiers in Immunology·Nicola TuminoLorenzo Moretta
Nov 26, 2020·Cancers·Enrico MaggiFrancesco Annunziato
May 14, 2021·Cellular & Molecular Immunology·Fei ShaoShuo Wang
May 18, 2021·Frontiers in Immunology·Kele CuiMin Cheng
Jul 1, 2021·European Journal of Immunology·Xiaodong YuanCheng Sun

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