ILC2 Orchestration of Local Immune Function in Adipose Tissue.

Frontiers in Immunology
Cécile Bénézech, Lucy Helen Jackson-Jones

Abstract

ILC2s were originally identified as IL-5 and IL-13 secreting "natural helper cells" present within the fat-associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include all ILC groups. Since their initial discovery, our knowledge of these cells and their role in adipose immune responses has expanded significantly. In this review we summarize the current literature on the role that ILC2s play in orchestrating adipose tissue function in both lean and obese states. We go on to address new data detailing interactions of adipose ILCs with innate like B-cells (IBC) and discuss how this interaction results in localized protection of mucosal sites during infection and inflammation via the production of innate antibodies.

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Citations

May 24, 2020·Acta Biochimica Et Biophysica Sinica·Wenping LiJin Jin
May 12, 2020·Immunology and Cell Biology·Katlin B StiversJames B Hoying
Nov 7, 2019·Diabetes & Metabolism Journal·Yea Eun KangMinho Shong
Mar 7, 2020·Frontiers in Immunology·Ahmed AbidiJérôme Martin
Jan 11, 2020·Frontiers in Microbiology·Christine BourgeoisOlivier Lambotte
Dec 8, 2020·Frontiers in Cardiovascular Medicine·Ibrahim AlZaimAhmed F El-Yazbi
Sep 4, 2020·Journal of Leukocyte Biology·Mingyong LiuSelene Meza-Perez
Apr 4, 2021·International Journal of Molecular Sciences·C Frieke KuperJolanda H M van Bilsen
Dec 24, 2020·Immunology and Cell Biology·Marlène MagalhaesCécile Bénézech
Apr 21, 2021·Current Opinion in Pharmacology·Gustavo Gastão DavanzoPedro Manoel M Moraes-Vieira
Jun 3, 2021·International Journal of Molecular Sciences·Rena KawanoMichiaki Fukui
Sep 17, 2021·Journal of Crohn's & Colitis·Roger SuauJosep Manyé
Dec 11, 2021·The Science of the Total Environment·Daniel J RawleAndreas Suhrbier

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Methods Mentioned

BETA
lavage

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