Jun 29, 2015

ILC2s and fungal allergy

Allergology International : Official Journal of the Japanese Society of Allergology
Hirohito Kita

Abstract

Innate lymphoid cells (ILCs) have emerged recently as an important component of the immune system and the cell type that regulates mucosal immune responses and tissue homeostasis. Group 2 ILCs (ILC2s), a subset of ILCs, reside in various tissues and are characterized by their capacity to produce type 2 cytokines and tissue growth factors. These ILC2s play an important role in allergic immune responses by linking signals in the atmospheric environment to the immune system. Fungi are one of the major allergens associated with human asthma, and animal and in vitro models using the fungal allergens have provided significant information toward our understanding of the mechanisms of allergic disease. In mouse models of fungus-induced allergic airway inflammation, IL-33, IL-25, and TSLP are released by airway epithelial cells. Lung ILC2s that respond to these cytokines quickly produce a large quantity of type 2 cytokines, resulting in airway eosinophilia, mucus production, and airway hyperreactivity even in the absence of adaptive immune cells. Evidence also suggests that ILC2s interact with conventional immune cells, such as CD4(+) T cells, and facilitate development of adaptive immune response and persistent airway inflammation. ILC...Continue Reading

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  • Citations11

Citations

Mentioned in this Paper

TSLP protein, human
Metabolic Process, Cellular
Eosinophil
Immune Response
Immune System
PTGDR2 gene
Leukotriene D4
Cd69
C19orf10 gene
RAG1 gene

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