Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Derek M CulnanRobert N Cooney

Abstract

The hindgut hypothesis posits improvements in Type 2 diabetes after gastric bypass surgery are due to enhanced delivery of undigested nutrients to the ileum, which increase incretin production and insulin sensitivity. The present study investigates the effect of ileal interposition (IT), surgically relocating a segment of distal ileum to the proximal jejunum, on glucose tolerance, insulin sensitivity, and glucose transport in the obese Zucker rat. Two groups of obese Zucker rats were studied: IT and sham surgery ad libitum fed (controls). Changes in food intake, body weight and composition, glucose tolerance, insulin sensitivity and tissue glucose uptake, and insulin signaling as well as plasma concentrations of glucagon-like peptide-1 and glucose-dependent insulinotropic peptide were measured. The IT procedure did not significantly alter food intake, body weight, or composition. Obese Zucker rats demonstrated improved glucose tolerance 3 wk after IT compared with the control group (P < 0.05). Euglycemic, hyperinsulinemic clamp and 1-[(14)C]-2-deoxyglucose tracer studies indicate that IT improves whole body glucose disposal, insulin-stimulated glucose uptake, and the ratio of phospho- to total Akt (P < 0.01 vs. control) in stri...Continue Reading

References

Jan 1, 1990·The American Journal of Physiology·D C ChenR L Atkinson
Oct 1, 1985·The American Journal of Physiology·G ManfrediniE Ferrannini
Oct 1, 1996·The American Journal of Physiology·T TsuchiyaP Tso
Jan 23, 1999·The Journal of Clinical Investigation·A DresnerG I Shulman
Jul 22, 1999·The New England Journal of Medicine·P R Shepherd, B B Kahn
Jul 10, 2003·Molecular and Cellular Endocrinology·A RedondoMaría L Villanueva-Peñacarrillo
Oct 8, 2003·Annals of Surgery·Philip R SchauerDavid Kelley
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·David E CummingsKaren E Foster-Schubert
Jun 17, 2004·The Journal of Biological Chemistry·Eric D WernerSteven E Shoelson
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Sep 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·April D StraderRandy J Seeley
Jun 16, 2005·Diabetes, Obesity & Metabolism·Desu Chen, Ming-Wei Wang
Nov 25, 2005·Molecular Medicine·Louise ChangAlan R Saltiel
Mar 17, 2006·The EMBO Journal·Sander M HoutenJohan Auwerx
Aug 24, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·David E CummingsUNKNOWN 2004 ABS Consensus Conference
Nov 2, 2006·Endocrine Reviews·Kevin G MurphyStephen R Bloom
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Jan 4, 2007·The Journal of Clinical Investigation·Daniel J Drucker
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Mar 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam T StearnsAli Tavakkolizadeh
Apr 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Blandine LaferrèreBlanca Olivan
Sep 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Benjamin T BikmanG Lynis Dohm
Jun 27, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brynn S WolffRobert N Cooney

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Citations

Dec 24, 2010·American Journal of Physiology. Endocrinology and Metabolism·Jay V PatankarSanja Levak-Frank
Oct 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A R RamzyP K Chelikani
Mar 20, 2013·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hideharu ShimizuStacy A Brethauer
Jun 15, 2012·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C JurowichA Thalheimer
Feb 2, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alper CelikMuhammad Abdul-Ghani
Jan 21, 2016·Asian Journal of Surgery·Sang Kuon LeeSay-June Kim
Jul 18, 2015·Journal of Diabetes Research·Christian Ferdinand JurowichHermann Koepsell
Jul 4, 2012·Journal of Hepatology·Jay V PatankarDagmar Kratky
Apr 10, 2017·Molecular Aspects of Medicine·Vance L AlbaughCharles R Flynn
May 31, 2016·F1000Research·Vance L AlbaughNaji N Abumrad
Feb 24, 2015·Obesity Surgery·Sawczyn TomaszKarcz Wojciech Kondrad

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