PMID: 8861482May 1, 1996Paper

Ileal nutritional function after one-stage orthotopic ileum transplantation in the growing pig: reversal of lethal short bowel syndrome

Journal of Pediatric Surgery
M PakarinenJ Halttunen

Abstract

Intestinal isolation is associated with hypoplasia of defunctioned mucosa and reduction in the segmental absorption, whereas the presence of luminal nutrition is essential for the expression of the ileal adaptive response after proximal small bowel resection. On the other hand, intensive postoperative graft monitoring is obligatory because of the disastrous consequences of small bowel graft rejection. Thus, the authors sought to develop an experimental ileum transplantation model that provided immediate graft placement in bowel continuity, together with readily available graft monitoring connection through a proximal Roux-en-Y enterostomy. Four groups of pigs were prepared: RESTX (n = 9), proximal 50% small bowel resection with simultaneous orthotopic ileum autotransplantation; RES (n = 7), proximal 50% small bowel resection; NONRES (n = 6), transection; and SB (n = 5), short bowel. Early (1 to 4 weeks) and long-term (5 to 12 weeks) studies of animal growth, nutritional status, disaccharide absorption, water and electrolyte balances, and liver function were performed after ileum autotransplantation (IAT) in relation to small intestine of variable length with undivided mesentery (intact neural and lymphatic connections). The per...Continue Reading

References

Sep 1, 1991·The Journal of Surgical Research·M G SarrA M Walters
May 1, 1989·Archives of Surgery·H KanekoR T Schweizer
Mar 1, 1989·Transplantation·M J StanglT Lee
Feb 1, 1989·The Journal of Surgical Research·S RajuJ L Achord
Mar 1, 1987·The British Journal of Surgery·A R DennisonP J Morris
Oct 1, 1987·Transplantation·H FujiwaraS Raju
Jun 1, 1985·The Journal of Surgical Research·T J PritchardR L Kirkman
Jul 1, 1984·The Journal of Surgical Research·T R BilliarW H Schraut
Dec 1, 1984·Transplantation·S RajuJ Achord
Jan 1, 1984·American Journal of Surgery·S NordgrenB Langer
Aug 1, 1995·Scandinavian Journal of Gastroenterology·M PakarinenP Kuusanmäki
Jan 1, 1994·American Journal of Surgery·C P JohnsonA M Roza
Jun 1, 1960·The Journal of Clinical Investigation·B BORGSTROM

❮ Previous
Next ❯

Citations

Apr 14, 2005·Pediatric Surgery International·Jouni LauronenTimo Paavonen
Dec 5, 1998·Transplantation Proceedings·K L ChanP K Tam
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Giovanni FrongiaArianeb Mehrabi
Feb 13, 2001·The Journal of Surgical Research·J LauronenT Paavonen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.