PMID: 8861482May 1, 1996Paper

Ileal nutritional function after one-stage orthotopic ileum transplantation in the growing pig: reversal of lethal short bowel syndrome

Journal of Pediatric Surgery
M PakarinenJ Halttunen


Intestinal isolation is associated with hypoplasia of defunctioned mucosa and reduction in the segmental absorption, whereas the presence of luminal nutrition is essential for the expression of the ileal adaptive response after proximal small bowel resection. On the other hand, intensive postoperative graft monitoring is obligatory because of the disastrous consequences of small bowel graft rejection. Thus, the authors sought to develop an experimental ileum transplantation model that provided immediate graft placement in bowel continuity, together with readily available graft monitoring connection through a proximal Roux-en-Y enterostomy. Four groups of pigs were prepared: RESTX (n = 9), proximal 50% small bowel resection with simultaneous orthotopic ileum autotransplantation; RES (n = 7), proximal 50% small bowel resection; NONRES (n = 6), transection; and SB (n = 5), short bowel. Early (1 to 4 weeks) and long-term (5 to 12 weeks) studies of animal growth, nutritional status, disaccharide absorption, water and electrolyte balances, and liver function were performed after ileum autotransplantation (IAT) in relation to small intestine of variable length with undivided mesentery (intact neural and lymphatic connections). The per...Continue Reading


Sep 1, 1991·The Journal of Surgical Research·M G SarrA M Walters
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Mar 1, 1987·The British Journal of Surgery·A R DennisonP J Morris
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Jun 1, 1985·The Journal of Surgical Research·T J PritchardR L Kirkman
Jul 1, 1984·The Journal of Surgical Research·T R BilliarW H Schraut
Dec 1, 1984·Transplantation·S RajuJ Achord
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Aug 1, 1995·Scandinavian Journal of Gastroenterology·M PakarinenP Kuusanmäki
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Jun 1, 1960·The Journal of Clinical Investigation·B BORGSTROM

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