Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats

Obesity Surgery
Tae Jung OhYoung Min Cho

Abstract

Chronic exposure to lipopolysaccharide (LPS) contributes to metabolic abnormalities, but there has been no study to evaluate plasma LPS levels after ileal transposition (IT). We examined the effect of IT on gut hormone secretion and plasma LPS levels and their correlation with metabolic parameters. Sprague-Dawley rats underwent either IT or sham operation. After 4 weeks, oral glucose tolerance tests (OGTT) were performed and fasting plasma LPS and gut histology were analyzed. Compared with the sham group, food intake and body weight decreased, and insulin sensitivity increased in the IT group. During the OGTTs, glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, and peptide YY (PYY) were significantly higher in the IT group than the sham group. The villi length, muscle thickness, and the density of GLP-1 and glucose-dependent insulinotropic polypeptide co-expressing cells (K/L-cells) increased in the transposed ileum compared with the ileum of the sham group. Fasting plasma LPS levels were lower in the IT group than the sham group (5.6 ± 0.2 vs. 6.8 ± 0.1 EU/ml, P = 0.002) and significantly correlated with insulin resistance (r = 0.755, P < 0.001). Plasma LPS levels were negatively correlated with PYY secretion (r = -0.710, P = 0...Continue Reading

References

Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·David E CummingsKaren E Foster-Schubert
Sep 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·April D StraderRandy J Seeley
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Feb 21, 2009·World Journal of Gastroenterology : WJG·Laurie A DrozdowskiAlan B R Thomson
Jul 16, 2009·Diabetes·Alessandro PocaiRanabir SinhaRoy
Jul 3, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rohit KohliRandy J Seeley
Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Derek M CulnanRobert N Cooney
Nov 26, 2010·Vitamins and Hormones·Young Min Cho, Timothy J Kieffer
Jan 29, 2011·Diabetes Care·Pirkko J PussinenVeikko Salomaa
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Madeleine SpeckTimothy J Kieffer
Aug 10, 2011·Nature Reviews. Endocrinology·Nathalie M DelzennePatrice D Cani
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
Mar 28, 2012·The New England Journal of Medicine·Geltrude MingroneFrancesco Rubino
Mar 28, 2012·The New England Journal of Medicine·Philip R SchauerDeepak L Bhatt
May 3, 2012·Endocrine Reviews·Margaret A StefaterRandy J Seeley
Jun 12, 2012·Lancet·John B DixonPaul Zimmet
Nov 20, 2012·Diabetes & Metabolic Syndrome·Sunil Kumar KotaKirtikumar D Modi
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Jul 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander D Miras, Carel W le Roux
Nov 20, 2013·Annual Review of Physiology·Young Min ChoTimothy J Kieffer
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Sten MadsbadJens J Holst
Mar 29, 2014·Nature·Karen K RyanRandy J Seeley
Oct 20, 2014·Acta Diabetologica·K A Elisa KallioPirkko J Pussinen

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