PMID: 11343934May 10, 2001Paper

Iliac crest biopsy versus rib segment resection for the detection of bone marrow isolated tumor cells from lung and esophageal cancer

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
S MattioliS Pileri

Abstract

The presence of isolated tumor cells in the bone marrow affects the prognosis of both esophageal cancer and non-small cell lung cancer (NSCLC). Therefore, preoperative assessment of isolated tumor cells may be useful to plan multimodality treatment. Rib segment resection at surgery provides adequate amounts of bone marrow for the detection of isolated tumor cells while bone marrow aspirate from the iliac crest does not. The iliac crest biopsy according to the Jamshidi technique procures a core of tissue apt for histology and not simply for cytology. The aim of this study was to compare the accuracy of iliac crest biopsy versus rib segment resection in the diagnosis of isolated tumor cells in order to obtain a useful preoperative approach. Twenty-one consecutive patients (18 NSCLC, three esophageal cancer) were evaluated. None had chemotherapy prior to evaluation. Bone marrow was obtained preoperatively by iliac crest biopsy using the Jamshidi needle and at surgery by rib segment resection. Positive cytokeratin neoplastic cells were searched by immunohistochemistry on tissue sections from the iliac crest biopsies and by flow cytometry on cell suspensions from the rib segments. Isolated tumor cells were detected in the rib segmen...Continue Reading

Citations

Aug 28, 2012·Annals of Thoracic Medicine·Gholamreza MohajeriMohsen Kolahdouzan
Feb 12, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Paal Fr BrunsvigOystein Fodstad
Jul 18, 2002·The Annals of Thoracic Surgery·Xiaolong Jiao, Mark J Krasna
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Sabine RiethdorfKlaus Pantel

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