ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance

Cancer Genomics & Proteomics
Dimitrios TsoumasVasiliki Bravou

Abstract

Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critically implicated in cancer metastasis and chemoresistance. Herein, we investigated integrin-linked kinase (ILK)'s role in human colon cancer (CRC) progression and chemoresistance in relation to EMT and CSC markers. Expression of ILK, EMT and CSC markers were evaluated by immunohistochemistry in 149 CRC samples. We also generated colon cancer cells resistant to 5-FU and oxaliplatin and studied the effect of ILK inhibition on drug response by MTT assay and on EMT and CSC markers' expression. ILK expression in human CRC correlates with EMT and CSC markers and is associated with metastasis and chemoresistance. ILK inhibition increases sensitivity of resistant cells to 5-FU and oxaliplatin and reduces the levels of EMT and CSC markers in 5-FU resistant cells. ILK overexpression in human CRC associates with EMT and CSC traits, contributing to tumor progression and chemoresistance.

Citations

Nov 30, 2019·Analytical Cellular Pathology (Amsterdam)·Monica NeaguMarieta Costache
Nov 24, 2019·Irish Journal of Medical Science·Min ShenYidao Jiang
Sep 29, 2020·Frontiers in Pharmacology·Jinyu ZhangYong Jiang
Jul 13, 2021·Oncoimmunology·Alexandre GhaziSophie Mouillet-Richard
Feb 1, 2020·Current Medicinal Chemistry·Jie ZhangWenjie Zheng

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