Illicit drug use and acute kidney injury in patients admitted to hospital with rhabdomyolysis

Internal Medicine Journal
Corinne Lau Hing YimAndy K H Lim

Abstract

Severe rhabdomyolysis is associated with acute kidney injury, but it is unclear if patients developing rhabdomyolysis after illicit drug use have a higher risk of acute kidney injury compared to other causes. To provide a descriptive analysis of patients admitted with rhabdomyolysis, with a focus on illicit drug use, and to determine if illicit drug use was an independent predictor for acute kidney injury or renal replacement therapy. We conducted a 5-year cohort study of patients admitted to Monash Health, a tertiary referral hospital network. We identified adult patients with muscle injury from ICD-10 AM codes, serum creatine kinase level greater than 1000 U/mL, and a clinical history consistent with rhabdomyolysis. We determined the prevalence and type of illicit drug involved and determined the association between illicit drug use and renal outcomes by logistic regression. Of 643 patients, illicit drug use was identified in 12%. Acute kidney injury developed in 51%, and 5% required renal replacement therapy. Compared to the rest of the cohort, patients who used illicit drugs were younger and had higher peak serum creatine kinase, and developed a higher severity of acute kidney injury. In multivariable analysis, the factors ...Continue Reading

References

Mar 22, 1990·The New England Journal of Medicine·O S Better, J H Stein
Dec 22, 1999·The American Journal of Emergency Medicine·J R RichardsR W Derlet
Oct 7, 2004·The American Journal of Medicine·Derek M FineJoseph A Eustace
Nov 4, 2005·Medicine·Giorgia MelliDavid R Cornblath
Dec 3, 2008·European Journal of Internal Medicine·Yiannis S ChatzizisisGeorge D Giannoglou
Jul 3, 2009·The New England Journal of Medicine·Xavier BoschJosep M Grau
Jun 12, 2010·Journal of Critical Care·Shunji KasaokaTsuyoshi Maekawa
Mar 17, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Edward D SiewJosh F Peterson
Dec 25, 2013·PloS One·Eva RodríguezJulio Pascual
Jul 19, 2014·Clinical Journal of the American Society of Nephrology : CJASN·William F PendergraftJohn L Niles
Jul 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Nadezda Petejova, Arnost Martinek
Jun 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Luis O ChavezJoseph Varon
Oct 27, 2017·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Marie VangstadDag Jacobsen
Dec 31, 2017·BMC Nephrology·Kanaan MansoorZeid J Khitan
Jan 9, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Nithin Abraham RajuSubramani Kandasamy

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Citations

Mar 25, 2020·World Journal of Gastroenterology : WJG·Andy Kh Lim
Apr 13, 2021·Clinical Kidney Journal·Mirna Aleckovic-HalilovicAlexander Woywodt
Jun 3, 2021·Journal of Clinical Medicine·Chien-Wen YangYichen Wang
Oct 2, 2021·Cannabis and Cannabinoid Research·Praveen K PotukuchiCsaba P Kovesdy

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