Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues

Immunity
Alex Y C HuangRonald N Germain

Abstract

A central feature of the immune system is the migratory behavior of its cellular components. Thus, fully understanding the generation and maintenance of immune responses must include consideration of how hematopoietic cells home to, interact within, and exit from secondary lymphoid organs as well as peripheral tissues. Recent advances in in situ imaging techniques now permit direct observation of these events in their physiologic settings with high spatiotemporal resolution. This review summarizes progress in this area of investigation from a lymphocentric perspective. We highlight controversies, point out key unanswered questions, and briefly outline what we believe are some of the near-term directions that in situ microscopic analysis of the immune system will take.

References

Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M L DustinE R Unanue
May 5, 1997·FEBS Letters·M OkabeY Nishimune
Jun 16, 1997·The Journal of Experimental Medicine·E IngulliM K Jenkins
Feb 7, 1998·The Journal of Experimental Medicine·R A WarnockU H von Andrian
Apr 16, 1998·The Journal of Investigative Dermatology·G WeinlichN Romani
Oct 6, 1998·Annual Review of Biochemistry·R Y Tsien
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A MiyawakiR Y Tsien
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Mar 29, 2001·Trends in Immunology·P Friedl, M Gunzer
Oct 3, 2001·The Journal of Experimental Medicine·W WeningerU H von Andrian
Dec 26, 2001·Experimental Hematology·J HardyC H Contag
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A Y TingR Y Tsien
Jun 8, 2002·Science·Sabine StollRonald N Germain
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aikaterini ZoumiBruce J Tromberg
Oct 23, 2002·The Journal of Experimental Medicine·Clemens ScheineckerRonald N Germain
Oct 26, 2002·Science·Michael L Dustin, David R Colman
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·Jin ZhangRoger Y Tsien
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Jul 2, 2003·The Journal of Experimental Medicine·Vincent HurezCasey T Weaver
Jul 26, 2003·Journal of Biomedical Optics·Mary E DickinsonScott E Fraser
Aug 6, 2003·Current Opinion in Immunology·Harvey R Herschman
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
Jan 22, 2004·Current Opinion in Immunology·Ronald N Germain, Marc K Jenkins
Mar 17, 2004·Biochemical and Biophysical Research Communications·Julia KalbRafael Kurtz

❮ Previous
Next ❯

Citations

Mar 4, 2008·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Masanari KoderaDouglas A Steeber
Jan 15, 2008·Nature Immunology·Heather D HickmanJonathan W Yewdell
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michio TomuraOsami Kanagawa
May 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jason M WeaverAndrea J Sant
May 18, 2005·The Journal of Experimental Medicine·Reinhard ObstChristophe Benoist
Mar 1, 2006·The Journal of Experimental Medicine·Marc BajénoffNicolas Glaichenhaus
Aug 23, 2006·The Journal of Experimental Medicine·Carlos BarciaPedro R Lowenstein
Feb 28, 2007·The Journal of Experimental Medicine·Tim WorbsReinhold Förster
Feb 28, 2007·The Journal of Experimental Medicine·César Nombela-ArrietaJens V Stein
Dec 6, 2006·The Journal of Experimental Medicine·Marcello ChieppaRonald N Germain
Mar 23, 2006·Annual Review of Immunology·Flora Castellino, Ronald N Germain
Jan 5, 2008·Annual Review of Immunology·Michael D Cahalan, Ian Parker
Nov 10, 2005·Arthritis Research & Therapy·Clemens Scheinecker
Feb 22, 2012·Journal of Visualized Experiments : JoVE·H L Rachel LiouAlex Y Huang
Jul 13, 2005·The Journal of Cell Biology·Joseph LinAndrey S Shaw
Jun 8, 2018·The Journal of Experimental Medicine·Federica MoalliJens V Stein
Sep 26, 2019·Frontiers in Immunology·Sujana SivapathamJens V Stein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Mark MillerIan Parker
Proceedings of the National Academy of Sciences of the United States of America
Mark MillerIan Parker
© 2021 Meta ULC. All rights reserved