Illusory movements prevent cortical disruption caused by immobilization

NeuroImage
R RollJean-Pierre Roll

Abstract

Enforced limb disuse strongly disrupts the cortical networks that are involved in sensorimotor activities. This disruption causes a cortical reorganization that may be functionally maladaptive. In this study, we used functional magnetic resonance imaging (fMRI) to investigate whether it is possible to prevent this reorganization by compensating for the lack of actual kinesthetic perception with illusory movements induced by "neuromimetic" proprio-tactile feedback that is artificially delivered during immobilization. Sixteen healthy volunteers were equipped for five days with full-hand ortheses that prevented them from performing finger and hand movements but allowed for kinesthetic and tactile sensations. Eight participants received a twice-daily proprio-tactile treatment consisting of the perception of kinesthetic sensations resembling those felt during actual movements generated by miniature vibrators set in the ortheses at the finger and wrist levels. Eight untreated participants received no stimulation. The effects of hand immobilization and treatment were assessed by fMRI during a calibrated voluntary hand movement task and hand tactile stimulation before cast placement and immediately after cast removal. We found that the...Continue Reading

Associated Clinical Trials

Jul 13, 2020·Bohumil Bakalar MD

References

Dec 1, 1995·Electroencephalography and Clinical Neurophysiology·J LiepertJ P Malin
Aug 1, 1997·Electroencephalography and Clinical Neurophysiology·G ZanetteA Fiaschi
Jan 7, 1998·Trends in Neurosciences·G Berlucchi, S Aglioti
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·K J Friston
Feb 16, 1999·Experimental Brain Research·S Calvin-FiguièreJ P Roll
Dec 1, 2001·Neuroreport·E Naito, H H Ehrsson
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Stefano FacchiniSalvatore M Aglioti
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Feb 19, 2003·Brain Research. Cognitive Brain Research·Patricia RomaiguèreJean-Pierre Roll
Jun 25, 2003·The Journal of Physiology·Karin Rosenkranz, John C Rothwell
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giampietro ZanetteStefano Tamburin
Apr 28, 2005·Experimental Brain Research·Frederic AlbertJean-Pierre Roll
Jul 19, 2005·Annual Review of Neuroscience·Alvaro Pascual-LeoneLotfi B Merabet
Jan 27, 2007·The Journal of Physiology·Jean-Marc AimonettiEdith Ribot-Ciscar
Mar 21, 2007·Nature Neuroscience·Mark Schram ChristensenJens Bo Nielsen
Nov 21, 2007·Neuropsychologia·A KavounoudiasR Roll
Apr 2, 2008·Behavioural Brain Research·Arturo Forner-CorderoStephan P Swinnen
May 3, 2008·Journal of Applied Physiology·Jesper Lundbye-Jensen, Jens Bo Nielsen
Aug 30, 2008·Journal of Cognitive Neuroscience·Marjolein P M KammersDennis J L G Schutter
Dec 5, 2008·Journal of Neurophysiology·Jean-Pierre RollBenjamin Mattei
Jan 27, 2009·Brain Research Reviews·Jörn MunzertKaren Zentgraf
Apr 29, 2009·Current Biology : CB·Silke LissekHubert R Dinse
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chloé Thyrion, Jean-Pierre Roll
Oct 13, 2009·Neuropsychologia·Manos Tsakiris
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karin RosenkranzJohn C Rothwell
Jun 12, 2010·Journal of Neurophysiology·Chloé Thyrion, Jean-Pierre Roll
Aug 17, 2010·NeuroImage·Oliver GranertHartwig R Siebner
Jan 18, 2012·Neurology·N LangerL Jäncke

❮ Previous
Next ❯

Citations

May 28, 2013·Cerebral Cortex·Laura AvanzinoMarco Bove
Feb 26, 2014·The Journal of Physiology·Riccardo ViaroGianfranco Franchi
Feb 26, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Christopher J PearceUNKNOWN ESKKA-AFAS Ankle Instability Group
Jul 15, 2015·Neuropsychologia·Laura AvanzinoMirta Fiorio
Dec 30, 2014·Frontiers in Human Neuroscience·Laura Avanzino, Mirta Fiorio
Jan 8, 2015·Frontiers in Systems Neuroscience·Mirco BudriGianfranco Franchi
Nov 25, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Robin SouronGuillaume Y Millet
Aug 2, 2018·Canadian Journal of Physiology and Pharmacology·Nicolas Fougeront, Bernard Fleiter
Oct 23, 2018·PloS One·Jean-Daniel DuboisCatherine Mercier
Aug 3, 2017·European Journal of Applied Physiology·Robin SouronThomas Lapole
Apr 8, 2017·Journal of Applied Physiology·Robin SouronThomas Lapole

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.