Iloprost has potent anti-inflammatory properties on human monocyte-derived dendritic cells

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
T MüllerMarco Idzko

Abstract

The stable prostaglandin I2 analogue (iloprost) iloprost has been shown to inhibit allergic airway inflammation in mice by modulating the function of myeloid dendritic cells (DCs). The aim of the current study was to investigate the biological activity of iloprost on human monocyte-derived DCs. I prostanoid (IP) receptor expression was analysed by RT-PCR. Cytokine secretion by DCs and CD4+ T cells was measured by ELISA. The expression of the transcription factor FoxP3 after co-culture of DCs with CD4+ CD45RA+ T cells was analysed by flow cytometry. Human monocyte-derived DCs were found to express mRNA specific for the PGI2 receptor IP, and stimulation with iloprost resulted in increased cyclic AMP levels in both immature DCs (iDCs) and mature DCs (mDCs). Moreover, iloprost dose dependently inhibited the secretion of TNF-alpha, IL-6, IL-8 and IL-12p70 in mDCs, while it enhanced IL-10 production. Changes in cytokine secretion were paralleled by an altered T-cell priming capacity of DCs: in co-culture experiments of iloprost-treated mDC and naïve CD45RA+ T cells, an induction of regulatory T cells could be observed, as demonstrated by increased intracellular FoxP3 expression and IL-10 production. Additionally, iloprost inhibited t...Continue Reading

References

Jul 1, 1993·The American Review of Respiratory Disease·I D PavordA E Tattersfield
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Sep 24, 1999·The Journal of Clinical Investigation·S H GavettD C Zeldin
Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Apr 20, 2001·The European Respiratory Journal·T GesslerW Seeger
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marco IdzkoJohannes Norgauer
Sep 19, 2002·British Journal of Pharmacology·Yoshimasa TakahashiHiroichi Nagai
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisabeth PantherJohannes Norgauer
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeina JaffarKevan Roberts
Apr 5, 2003·American Journal of Respiratory Cell and Molecular Biology·Koichi NagaoHiroichi Nagai
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michelle A CareyDarryl C Zeldin
Dec 4, 2003·Nature Reviews. Immunology·Martien L Kapsenberg
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rachel J A HelliwellMurray D Mitchell
Sep 18, 2004·Cancer Letters·Shan ZhaAngelo M De Marzo
Mar 23, 2005·The Journal of Experimental Medicine·Leonie S van RijtBart N Lambrecht
Apr 5, 2005·Nature Immunology·Tomonori KunikataShuh Narumiya
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gye Young Park, John W Christman
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noelia Sánchez-SánchezJosé Luis Rodríguez-Fernández
May 6, 2006·The Journal of Allergy and Clinical Immunology·Naomi YamashitaKen Ohta
Nov 3, 2006·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weisong ZhouR Stokes Peebles
Feb 3, 2007·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Sep 14, 2007·Immunological Reviews·Hideki UenoJacques Banchereau
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie W T LauJohn V Forrester
Apr 2, 2008·The European Respiratory Journal·M Gomberg-Maitland, H Olschewski
Jun 20, 2008·Journal of Leukocyte Biology·Antonella D'AmbrosioMonica Boirivant
Jul 10, 2008·Journal of Leukocyte Biology·Christine LagaraineYvon Lebranchu
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanuelle HenryFabrice Bureau
Jun 2, 2009·Lancet·Peter J Barnes, Ian M Adcock

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Citations

Dec 4, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Sep 17, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Wenxuan LiuChunling Ma
Oct 15, 2005·American Journal of Respiratory Cell and Molecular Biology·Matiur RahamanMarie-Thérèse Walsh
Dec 17, 2010·BMC Immunology·Patrizia D'AmelioGiovanni C Isaia
Aug 2, 2012·Mediators of Inflammation·Stacy L Dorris, R Stokes Peebles
Dec 30, 2014·Expert Review of Respiratory Medicine·Dru ClaarRay Stokes Peebles
Dec 3, 2015·Mucosal Immunology·M WeitnauerA H Dalpke
Nov 24, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C H KatelarisP Wark
Sep 29, 2004·Cytokine & Growth Factor Reviews·Michel Dy, Elke Schneider
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Sachiko SaekiShigeru Kohno
Nov 11, 2018·Pflügers Archiv : European journal of physiology·Yingxue CaoChuan-Ming Hao
Apr 27, 2019·Frontiers in Immunology·Sebastian WendlerKatharina Schmidt-Bleek
Aug 18, 2021·Clinical Science·William S Powell

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