Image analysis of nuclear/cytoplasmic ratio in cervical smears to discriminate three grades of cervical intraepithelial neoplasia

Acta Cytologica
M Y MaedaV A Alves

Abstract

To suggest which system of cytologic classification (Bethesda System or World Health Organization [WHO]) of cervical lesions is more adequate for the Public Health Service of São Paulo State, Brazil, based on morphometric study with the Jandel Videoanalysis (JAVA) System. The study comprised groups of typical smears: cervical intraepithelial neoplasia (CIN 1) separated into two subgroups: cytopathic effects of human papillomavirus associated or not with dyskaryosis, CIN 2 and CIN 3. The JAVA system of image analysis was used to determine the nuclear/cytoplasmic (N/C) ratio in abnormal cells from each group. Significant differences were detected between the three grades of CIN and between the two subgroups of CIN 1. Although image analysis is not applicable to large-scale population screening of cervical smears, its use in the present study favored the three-grade cytologic classification (WHO). In addition, the three-grade classification offers the clinician more options for treatment. Considering the clinical-laboratory characteristics of our public health service, the three-grade classification is more adequate.

Citations

Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Volker Schneider
Jul 23, 2013·Journal of Pathology Informatics·Seung ParkLiron Pantanowitz
Sep 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sandra AlbertiLuís A A Taveira
Jan 1, 2014·Journal of Diabetes and Metabolic Disorders·Safoura SeifiBabak Zamani
Mar 15, 2003·Physiological Measurement·D C WalkerR H Smallwood
Nov 6, 2020·Journal of Pharmacy & Bioallied Sciences·Kavitha GaddikeriDeepak Bhorgonde

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