Image-Based 2D Re-Projection for Attenuation Substitution in PET Neuroimaging

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Charles M LaymonJames M Mountz

Abstract

In dual modality positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) methods are continually improving. Although a new AC can sometimes be generated from existing MR data, its application requires a new reconstruction. We evaluate an approximate 2D projection method that allows offline image-based reprocessing. 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) brain scans were acquired (Siemens HR+) for six subjects. Attenuation data were obtained using the scanner's transmission source (SAC). Additional scanning was performed on a Siemens mMR including production of a Dixon-based MR AC (MRAC). The MRAC was imported to the HR+ and the PET data were reconstructed twice: once using native SAC (ground truth); once using the imported MRAC (imperfect AC). The re-projection method was implemented as follows. The MRAC PET was forward projected to approximately reproduce attenuation-corrected sinograms. The SAC and MRAC images were forward projected and converted to attenuation-correction factors (ACFs). The MRAC ACFs were removed from the MRAC PET sinograms by division; the SAC ACFs were applied by multiplication. The regenerated sinograms were reconstructed by filtered back projection to produce ...Continue Reading

References

Oct 1, 1984·Radiology·W T Dixon
Apr 1, 1997·IEEE Transactions on Medical Imaging·M DefriseD F Newport
Jul 5, 2001·IEEE Transactions on Medical Imaging·M A AnastasioE Clarkson
Jan 1, 1994·IEEE Transactions on Medical Imaging·H M Hudson, R S Larkin
Jan 1, 1982·IEEE Transactions on Medical Imaging·L A Shepp, Y Vardi
Apr 18, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Alireza AhmadianHabib Zaidi
Dec 24, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Matthias HofmannThomas Beyer
Mar 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Axel Martinez-MöllerStephan G Nekolla
May 5, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vincent KeeremanStefaan Vandenberghe
Sep 3, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ciprian CatanaA Gregory Sorensen
Aug 11, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias HofmannBernhard Schölkopf
Nov 28, 2012·Seminars in Nuclear Medicine·Ilja BezrukovBernd J Pichler
Oct 4, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David Izquierdo-GarciaCiprian Catana
May 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniel H PaulusThomas Koesters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.