Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies

NeuroImage
Jurgen E M MourikRonald Boellaard

Abstract

The High Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. The aim of the present study was to validate the use of image derived input functions (IDIF) as an alternative for arterial sampling for HRRT human brain studies. To this end, IDIFs were extracted from 3D ordinary Poisson ordered subsets expectation maximization (OP-OSEM) and reconstruction based partial volume corrected (PVC) OP-OSEM images. IDIFs, either derived directly from regions of interest or further calibrated using manual samples taken during scans, were evaluated for dynamic [(11)C]flumazenil data (n=6). Results obtained with IDIFs were compared with those obtained using blood sampler input functions (BSIF). These comparisons included areas under the curve (AUC) for peak (0-3.3 min) and tail (3.3-55.0 min). In addition, slope, intercept and Pearson's correlation coefficient of tracer kinetic analysis results based on IDIF and BSIF were calculated for each subject. Good peak AUC ratios (0.83+/-0.21) between IDIF and BSIF were found for calibrated IDIFs extracted from OP-OSEM images. This combination of IDIFs and images also provided good slope values (1.07+/-0.11). Improved resolution, as obtained with ...Continue Reading

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Citations

May 8, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jurgen E M MourikRonald Boellaard
Jul 5, 2012·Nuclear Medicine Communications·Paolo Zanotti-FregonaraRobert B Innis
Feb 3, 2011·Nuklearmedizin. Nuclear Medicine·H HerzogN J Shah
Jul 3, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Virginie FringsRonald Boellaard
Jul 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jurgen E M MourikRonald Boellaard
Nov 26, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Jurgen E M MourikRonald Boellaard
Feb 5, 2013·Nuclear Medicine and Biology·Andreas HahnRupert Lanzenberger
Aug 4, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paolo Zanotti-FregonaraRobert B Innis
Jul 9, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paolo Zanotti-FregonaraRégine Trébossen
Jul 6, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Etienne CroteauRobert A deKemp
Oct 22, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jurgen E M MourikRonald Boellaard
Apr 11, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin SchainAndrea Varrone
Jan 27, 2017·PloS One·Marie MeyerPaolo Zanotti-Fregonara
May 24, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lalith Ks SundarThomas Beyer
Jan 16, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie B AndersenIan Law
Feb 10, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Samuel KuttnerJan Axelsson
May 1, 2021·Sensors·Héctor Espinós-MoratóMaría José Rodríguez-Álvarez
Apr 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Floris H P van VeldenRonald Boellaard

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