Image guidance in radiation therapy for better cure of cancer.

Molecular Oncology
Vincent GrégoireDaniel Zips

Abstract

The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs. Radiation doses required to achieve sufficient cancer-cell kill exceed in most clinical situations the dose that can be tolerated by the healthy tissues, especially when large parts of the affected organ are irradiated. High-precision radiation oncology aims at optimizing tumor coverage, while sparing normal tissues. Medical imaging during the preparation phase, as well as in the treatment room for localization of the tumor and directing the beam, referred to as image-guided radiotherapy (IGRT), is the cornerstone of precision radiation oncology. Sophisticated high-resolution real-time IGRT using X-rays, computer tomography, magnetic resonance imaging, or ultrasound, enables delivery of high radiation doses to tumors without significant damage of healthy organs. IGRT is the most convincing success story of radiation oncology over the last decades, and it remains a major driving force of innovation, contributing to the development of personalized oncology, for example, through the use of real-time imaging biomarkers for individualized dose delivery.

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Citations

Jul 3, 2020·Molecular Oncology·Michael Baumann, Carol Bacchus
Dec 19, 2020·Clinical and Translational Radiation Oncology·Pierluigi BonomoCihan Gani
Feb 16, 2021·Frontiers in Oncology·Petra J van HoudtUulke A van der Heide
Feb 3, 2021·Cancers·Tord HomplandHeidi Lyng
Feb 27, 2021·Radiation Oncology·Richard KlausBärbel Lange-Sperandio
Mar 26, 2021·Frontiers in Oncology·Daniela Thorwarth, Daniel A Low
Apr 6, 2021·Frontiers in Oncology·Simon BoekePanagiotis Balermpas
May 29, 2021·Radiology. Imaging Cancer·Christina H Liu, Piotr Grodzinski

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Methods Mentioned

BETA
X‐ray
imaging techniques
surgical resection

Clinical Trials Mentioned

NCT02853110
NCT02960087
NCT04100174

Software Mentioned

SMART
IDEAL
IGRT
ViewRay
Elekta
EMBRACE
ART
MRIdian
retroEMBRACE
Varian

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