Image-guided adaptive gating of lung cancer radiotherapy: a computer simulation study

Physics in Medicine and Biology
Michalis AristophanousRoss I Berbeco

Abstract

The purpose of this study is to investigate the effect that image-guided adaptation of the gating window during treatment could have on the residual tumor motion, by simulating different gated radiotherapy techniques. There are three separate components of this simulation: (1) the 'Hokkaido Data', which are previously measured 3D data of lung tumor motion tracks and the corresponding 1D respiratory signals obtained during the entire ungated radiotherapy treatments of eight patients, (2) the respiratory gating protocol at our institution and the imaging performed under that protocol and (3) the actual simulation in which the Hokkaido Data are used to select tumor position information that could have been collected based on the imaging performed under our gating protocol. We simulated treatments with a fixed gating window and a gating window that is updated during treatment. The patient data were divided into different fractions, each with continuous acquisitions longer than 2 min. In accordance to the imaging performed under our gating protocol, we assume that we have tumor position information for the first 15 s of treatment, obtained from kV fluoroscopy, and for the rest of the fractions the tumor position is only available du...Continue Reading

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Citations

Mar 9, 2013·Journal of Applied Clinical Medical Physics·Sarah QuirkW L Smith
Feb 14, 2015·Journal of Applied Clinical Medical Physics·R Alfredo SiochiSudershan Bhatia
Apr 9, 2014·Physics in Medicine and Biology·Mengjiao WangGuangzhi Wang

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