Image-guided cancer therapy using PET/CT

The Cancer Journal
Jeffrey T YapDavid W Townsend

Abstract

Functional imaging with positron emission tomography (PET) is playing an increasingly important role in the diagnosis and staging of malignant disease, image-guided therapy planning, and treatment monitoring. PET scanning with the radiolabeled glucose analogue (18)F-fluorodeoxyglucose ((18)FDG) is a relatively recent addition to the clinically available technology for imaging cancer, complementing the more conventional anatomical imaging modalities of computed tomography (CT) and magnetic resonance (MR). These modalities are complementary in the sense that CT provides accurate localization of organs and lesions while PET maps both normal and abnormal tissue function. When combined, the two modalities can identify and localize functional abnormalities. Attempts to align CT and PET data sets with fusion software are generally successful in the brain, whereas the remainder of the body is more challenging owing to the increased number of possible degrees of freedom between the two scans. Recently these challenges have been addressed by the introduction of the combined PET/CT scanner, a hardware-oriented approach to image fusion. With this device, accurately registered anatomical and functional images can be acquired for each patien...Continue Reading

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