Abstract
Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for the patient. In order to remove the tumor tissue completely with minimal collateral damage to healthy tissue, there is a need for diagnostic tools that will differentiate between the tumor and its normal surroundings. Methods: We designed, synthesized and characterized three novel polymeric Turn-ON probes that will be activated at the tumor site by cysteine cathepsins that are highly expressed in multiple tumor types. Utilizing orthotopic breast cancer and melanoma models, which spontaneously metastasize to the brain, we studied the kinetics of our polymeric Turn-ON nano-probes. Results: To date, numerous low molecular weight cathepsin-sensitive substrates have been reported, however, most of them suffer from rapid clearance and reduced signal shortly after administration. Here, we show an improved tumor-to-background ratio upon activation of our Turn-ON probes by cathepsins. The signal obtained...Continue Reading
Citations
Dec 24, 2018·Expert Opinion on Drug Delivery·Manju SharmaJiban Jyoti Panda
Jan 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Neja ŠamecIvana Jovčevska
Feb 6, 2020·Small·Hong LiangYu Nie
Apr 2, 2020·Expert Opinion on Therapeutic Targets·Matej VizovišekBoris Turk
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Nov 23, 2018·Nanomaterials·Ryan M DavisCristina Zavaleta
Sep 21, 2019·Advanced Materials·Cong WangXiaoyuan Chen
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Oct 8, 2019·Chemical Science·Dan WuDonal F O'Shea
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·A A BogdanovA P Savitsky
Dec 24, 2019·Frontiers in Chemistry·Maria L OdyniecTony D James
Jan 16, 2021·Advanced Healthcare Materials·Enyun XingShuxian Meng
Dec 8, 2020·Acta Biomaterialia·Dan YangChuanbin Wu
Nov 17, 2020·Frontiers in Oncology·Sergi BenaventeJuan Lorente
Apr 4, 2021·International Journal of Molecular Sciences·Matej VizovisekSimone Schuerle
Mar 30, 2021·Frontiers in Bioengineering and Biotechnology·Mengqi GuanShanshan Li
Jun 24, 2021·ACS Applied Materials & Interfaces·Zhongrui ChenOlivier Siri
Aug 6, 2019·Biomacromolecules·Eva Kopansky-GroismanAyelet David
Aug 25, 2020·Biomacromolecules·Merav SegalRoey J Amir
Jan 15, 2021·ACS Applied Materials & Interfaces·Chuanhui SongWei Han
Nov 28, 2021·Small·Jinrong ZhengMangmang Sang
Dec 7, 2021·ACS Applied Materials & Interfaces·Mangmang SangJinrong Zheng
Dec 21, 2021·Chemical Society Reviews·Yan ZhangKanyi Pu