Image monitoring of pharmaceutical blending processes and the determination of an end point by using a portable near-infrared imaging device based on a polychromator-type near-infrared spectrometer with a high-speed and high-resolution photo diode array detector

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Kodai MurayamaYukihiro Ozaki

Abstract

In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.

References

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Nov 6, 2001·Drug Development and Industrial Pharmacy·C Ufret, K Morris
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Jul 21, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaap van der Weerd, Sergei G Kazarian
Jan 24, 2007·Journal of Pharmaceutical Sciences·Makoto OtsukaYukihiro Ozaki
Jul 7, 2007·Pharmaceutical Research·Sergei G Kazarian, Jaap van der Weerd
Oct 24, 2007·International Journal of Pharmaceutics·Weiyong LiDenita Winstead
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Jun 26, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yukihiro Ozaki
Nov 8, 2013·Analytical and Bioanalytical Chemistry·Daitaro IshikawaYukihiro Ozaki

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