Image quality and safety after iodixanol in intravenous urography; a comparison with iohexol

The British Journal of Radiology
P SundgrenT Almén

Abstract

A double-blind, randomized phase III study compared intravenous urography in 100 adult patients receiving iodixanol 320 mgI ml-1 (Visipaque) with 99 patients receiving iohexol 350 mgI ml-1 (Omnipaque). The aim of the study was to investigate differences in image quality between a non-ionic dimeric contrast medium (CM) and a non-ionic monomer at 40 ml per patient and 60-100 ml per patient volume levels. There were no statistically significant differences between iodixanol and iohexol with respect to overall diagnostic information, which was found to be optimal in 86% and 79%, respectively. Immediately after the injection, the renal border was better delineated with iohexol than with iodixanol (p = 0.0001). Marked papillary blush occurred more often in the iodixanol group (16%) than in the iohexol group (0%), as did visualization of the collecting ducts (24% vs 5%) (p = 0.001). The incidence of adverse events was similar and low for both contrast media. In patients who received the higher doses of CM (60-100 ml), the frequency of discomfort was significantly lower after iodixanol than after iohexol (p = 0.006). We conclude that, in intravenous urography, iodixanol provides at least as good image quality as does iohexol. Iodixanol...Continue Reading

References

Feb 1, 1992·Investigative Radiology·M G SvalandP A Hals
Feb 1, 1986·Urology·T L MullinsF J Doherty
Nov 1, 1994·Acta Radiologica·A FlinckS Ekholm
Jan 1, 1995·Acta Radiologica. Supplementum·E F GrabowskiA D Michelson
May 8, 1994·Quality in Health Care : QHC·T Henry

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