PMID: 29756127Jan 1, 2017Paper

Image Segmentation and Modeling of the Pediatric Tricuspid Valve in Hypoplastic Left Heart Syndrome

Functional Imaging and Modeling of the Heart : ... International Workshop, FIMH ..., Proceedings
Alison M PouchMatthew A Jolley

Abstract

Hypoplastic left heart syndrome (HLHS) is a single-ventricle congenital heart disease that is fatal if left unpalliated. In HLHS patients, the tricuspid valve is the only functioning atrioventricular valve, and its competence is therefore critical. This work demonstrates the first automated strategy for segmentation, modeling, and morphometry of the tricuspid valve in transthoracic 3D echocardiographic (3DE) images of pediatric patients with HLHS. After initial landmark placement, the automated segmentation step uses multi-atlas label fusion and the modeling approach uses deformable modeling with medial axis representation to produce patient-specific models of the tricuspid valve that can be comprehensively and quantitatively assessed. In a group of 16 pediatric patients, valve segmentation and modeling attains an accuracy (mean boundary displacement) of 0.8 ± 0.2 mm relative to manual tracing and shows consistency in annular and leaflet measurements. In the future, such image-based tools have the potential to improve understanding and evaluation of tricuspid valve morphology in HLHS and guide strategies for patient care.

Citations

Nov 6, 2018·Canadian Journal of Physiology and Pharmacology·Kaley H Garner, Dinender K Singla
Aug 14, 2018·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Matthew A JolleyDavid M Harrild

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