Imaginal tissues of Drosophila melanogaster exhibit different modes of cell proliferation control

Developmental Biology
P Kylsten, R Saint

Abstract

The highly conserved regulatory mechanisms that control progression of a cell through the cell cycle do not, alone, explain the programmed control of cell proliferation during animal development. Additional controls must coordinate the cell cycle regulators with developmental regulatory events. Here we report studies of cell cycle control in the imaginal tissues of Drosophila melanogaster, specifically in situations where cell cycle progression is regulated by varying the length of the G2 phase. We show that G2-phase arrest in late larval wing imaginal disks requires transcriptional control of stg, a mitotic inducer that encodes a D. melanogaster homologue of the Schizosaccharomyces pombe p80cdc25 phosphatase. In a second study, string transcriptional regulation was also shown to be important for G2-phase regulation in eye disk cells posterior to the morphogenetic furrow. Finally, unlike all other situations described to date, string transcriptional regulation was found not to be the cause of G2 arrest in abdominal histoblasts, these cells being refractory to ectopic expression of stg. This study further establishes string as an important regulator of G2 phase during D. melanogaster development, but also reveals that at least o...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1990·Journal of Cell Science. Supplement·P J Bryant, O Schmidt
Jan 1, 1990·Methods in Cell Biology·L Vindeløv, I J Christensen
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K SadhuP Russell
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N ItohP M Salvaterra
Sep 1, 1987·Developmental Biology·M Schubiger, J Palka
Oct 1, 1971·Developmental Biology·A Garcia-Bellido, J R Merriam
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E A Nigg
Aug 18, 1994·Nature·A Busturia, P A Lawrence
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MilánA García-Bellido
Sep 1, 1987·Developmental Biology·A Tomlinson, D F Ready
Apr 1, 1987·Developmental Biology·A Tomlinson, D F Ready
Dec 1, 1977·Wilhelm Roux's Archives of Developmental Biology·M Mandaravally Madhavan, Howard A Schneiderman
Sep 1, 1979·Wilhelm Roux's Archives of Developmental Biology·Craig R Roseland, Howard A Schneiderman
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·G JürgensH Kluding

❮ Previous
Next ❯

Citations

Oct 23, 2009·Molecular Biology of the Cell·Li-Fang ShyuWu-Min Deng
Apr 13, 2011·Molecular and Cellular Biology·Yu-Ichiro NakajimaMasayuki Miura
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·J Robert ManakJoseph S Lipsick
May 14, 2016·Cell Death and Differentiation·M Eroglu, W B Derry
Feb 1, 2003·Mechanisms of Development·Nicolas NègreAnne Marie Martinez
Oct 15, 2009·Mechanisms of Development·Aishwarya Swaminathan, Lori A Pile

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.